What compounds target ACVR1?

BiohacksAI has identified 31 compounds that interact with ACVR1 (activin A receptor type 1). Top compounds include: alvocidib, tozasertib, vandetanib, nintedanib, canertinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ACVR1 (activin A receptor)?

ACVR1 is activin A receptor type 1. It is a molecular target for 31 compounds documented in PubMed bioassay data. UniProt ID: Q04771. NCBI Gene ID: 90.

ACVR1

MOLECULAR TARGET

activin A receptor type 1

UniProt: Q04771 NCBI Gene: 9031 compounds

ACVR1 (activin A receptor type 1) is targeted by 31 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ACVR1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	alvocidib	4.52	91
2	tozasertib	4.33	75
3	vandetanib	4.30	73
4	nintedanib	3.61	36
5	canertinib	3.53	33
6	tae 684	3.43	30
7	fedratinib	3.40	29
8	gilteritinib	3.40	29
9	saracatinib	3.33	27
10	sgi 1776	3.26	25
11	tandutinib	3.22	24
12	dorsomorphin	3.14	22
13	jnj 7706621	3.09	21
14	at 9283	3.09	21
15	lestaurtinib	3.04	20
16	pacritinib	3.04	20
17	danusertib	2.94	18
18	momelotinib	2.89	17
19	r 406	2.83	16
20	cediranib	2.83	16
21	pd 0166285	2.83	16
22	milciclib	2.77	15
23	kw 2449	2.64	13
24	mk 5108	2.48	11
25	lorlatinib	2.48	11
26	aee 788	2.30	9
27	gsk 1070916	2.20	8
28	cyc 116	2.08	7
29	ravoxertinib	2.08	7
30	Crizotinib	0.69	1
31	Dasatinib	0.69	1

About ACVR1 as a Drug Target

ACVR1 (activin A receptor type 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 31 compounds with documented ACVR1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ACVR1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.