AKR1C3
MOLECULAR TARGETaldo-keto reductase family 1 member C3
AKR1C3 (aldo-keto reductase family 1 member C3) is targeted by 24 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting AKR1C3
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | diclofenac sodium | 4.52 | 91 |
| 2 | flurbiprofen | 4.33 | 75 |
| 3 | caffeic acid phenethyl ester | 4.25 | 69 |
| 4 | flufenamic acid | 4.14 | 62 |
| 5 | mefenamic acid | 3.93 | 50 |
| 6 | dinaciclib | 3.87 | 47 |
| 7 | meclofenamic acid | 3.50 | 32 |
| 8 | buparlisib | 3.40 | 29 |
| 9 | tolfenamic acid | 3.09 | 21 |
| 10 | dexibuprofen | 3.00 | 19 |
| 11 | fenamic acid | 2.71 | 14 |
| 12 | 2 hydroxy flavanone | 2.71 | 14 |
| 13 | drupanin | 2.30 | 9 |
| 14 | artepillin | 2.20 | 8 |
| 15 | baccharin | 2.08 | 7 |
| 16 | Indomethacin | 1.79 | 5 |
| 17 | rs roscovitine | 1.79 | 5 |
| 18 | 6 methoxy 2 naphthylacetic acid | 1.79 | 5 |
| 19 | jasmonic acid | 1.79 | 5 |
| 20 | Naproxen | 1.61 | 4 |
| 21 | Medroxyprogesterone Acetate | 1.39 | 3 |
| 22 | Berberine | 1.10 | 2 |
| 23 | Linoleic Acid | 1.10 | 2 |
| 24 | Bimatoprost | 0.69 | 1 |
About AKR1C3 as a Drug Target
AKR1C3 (aldo-keto reductase family 1 member C3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 24 compounds with documented AKR1C3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
AKR1C3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.