What compounds target CDK16?

BiohacksAI has identified 52 compounds that interact with CDK16 (cyclin dependent kinase 16). Top compounds include: seliciclib, alvocidib, foretinib, tozasertib, ponatinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CDK16 (cyclin dependent kinase)?

CDK16 is cyclin dependent kinase 16. It is a molecular target for 52 compounds documented in PubMed bioassay data. UniProt ID: Q00536. NCBI Gene ID: 5127.

CDK16

MOLECULAR TARGET

cyclin dependent kinase 16

UniProt: Q00536 NCBI Gene: 512752 compounds

CDK16 (cyclin dependent kinase 16) is targeted by 52 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CDK16

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	seliciclib	4.91	135
2	alvocidib	4.52	91
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	ponatinib	4.26	70
6	palbociclib	4.22	67
7	bosutinib	4.08	58
8	quizartinib	3.99	53
9	dinaciclib	3.87	47
10	silmitasertib	3.78	43
11	pazopanib	3.69	39
12	neratinib	3.66	38
13	abemaciclib	3.66	38
14	nintedanib	3.61	36
15	rucaparib	3.58	35
16	pelitinib	3.50	32
17	bms 387032	3.47	31
18	tae 684	3.43	30
19	fedratinib	3.40	29
20	linifanib	3.33	27
21	at 7519	3.33	27
22	dabrafenib	3.30	26
23	ribociclib	3.26	25
24	tandutinib	3.22	24
25	sp 600125	3.22	24
26	dovitinib	3.09	21
27	jnj 7706621	3.09	21
28	at 9283	3.09	21
29	lestaurtinib	3.04	20
30	pacritinib	3.04	20
31	adavosertib	3.04	20
32	pf 03758309	3.00	19
33	ruboxistaurin	2.94	18
34	defosbarasertib	2.89	17
35	momelotinib	2.89	17
36	milciclib	2.77	15
37	pf 00562271	2.77	15
38	pha 665752	2.71	14
39	bms 345541	2.71	14
40	kw 2449	2.64	13
41	ast 487	2.56	12
42	zotiraciclib	2.56	12
43	su 014813	2.20	8
44	rebastinib	2.20	8
45	cyc 116	2.08	7
46	enzastaurin	2.08	7
47	rg 547	2.08	7
48	uprosertib	1.95	6
49	Axitinib	0.69	1
50	indirubin	0.69	1

Showing top 50 of 52 compounds. Use the BiohacksAI search to explore all CDK16 modulators.

About CDK16 as a Drug Target

CDK16 (cyclin dependent kinase 16) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 52 compounds with documented CDK16 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CDK16 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.