CILK1
MOLECULAR TARGETciliogenesis associated kinase 1
CILK1 (ciliogenesis associated kinase 1) is targeted by 24 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting CILK1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | alvocidib | 4.52 | 91 |
| 2 | dinaciclib | 3.87 | 47 |
| 3 | midostaurin | 3.85 | 46 |
| 4 | silmitasertib | 3.78 | 43 |
| 5 | abemaciclib | 3.66 | 38 |
| 6 | nintedanib | 3.61 | 36 |
| 7 | bms 387032 | 3.47 | 31 |
| 8 | tae 684 | 3.43 | 30 |
| 9 | fedratinib | 3.40 | 29 |
| 10 | at 7519 | 3.33 | 27 |
| 11 | lestaurtinib | 3.04 | 20 |
| 12 | pacritinib | 3.04 | 20 |
| 13 | pf 03758309 | 3.00 | 19 |
| 14 | ruboxistaurin | 2.94 | 18 |
| 15 | momelotinib | 2.89 | 17 |
| 16 | milciclib | 2.77 | 15 |
| 17 | sotrastaurin | 2.77 | 15 |
| 18 | pha 665752 | 2.71 | 14 |
| 19 | kw 2449 | 2.64 | 13 |
| 20 | ast 487 | 2.56 | 12 |
| 21 | su 014813 | 2.20 | 8 |
| 22 | enzastaurin | 2.08 | 7 |
| 23 | rg 547 | 2.08 | 7 |
| 24 | pictilisib | 0.69 | 1 |
About CILK1 as a Drug Target
CILK1 (ciliogenesis associated kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 24 compounds with documented CILK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
CILK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.