What compounds target CLK2?

BiohacksAI has identified 52 compounds that interact with CLK2 (CDC like kinase 2). Top compounds include: epigalocatechin gallate, seliciclib, alvocidib, ruxolitinib, pi 103. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CLK2 (CDC like kinase)?

CLK2 is CDC like kinase 2. It is a molecular target for 52 compounds documented in PubMed bioassay data. UniProt ID: P49760. NCBI Gene ID: 1196.

CLK2

MOLECULAR TARGET

CDC like kinase 2

UniProt: P49760 NCBI Gene: 119652 compounds

CLK2 (CDC like kinase 2) is targeted by 52 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CLK2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	epigalocatechin gallate	5.40	220
2	seliciclib	4.91	135
3	alvocidib	4.52	91
4	ruxolitinib	4.23	68
5	pi 103	4.17	64
6	bosutinib	4.08	58
7	bi 2536	4.01	54
8	midostaurin	3.85	46
9	brigatinib	3.81	44
10	silmitasertib	3.78	43
11	abemaciclib	3.66	38
12	nintedanib	3.61	36
13	pelitinib	3.50	32
14	bms 387032	3.47	31
15	tae 684	3.43	30
16	fedratinib	3.40	29
17	mln 8054	3.33	27
18	at 7519	3.33	27
19	tandutinib	3.22	24
20	sp 600125	3.22	24
21	alectinib	3.18	23
22	dovitinib	3.09	21
23	jnj 7706621	3.09	21
24	lestaurtinib	3.04	20
25	ruboxistaurin	2.94	18
26	r 406	2.83	16
27	k 252a	2.83	16
28	sotrastaurin	2.77	15
29	pha 665752	2.71	14
30	plx 4720	2.71	14
31	kw 2449	2.64	13
32	gsk 690693	2.64	13
33	mli 2	2.64	13
34	ast 487	2.56	12
35	su 014813	2.20	8
36	leucettamine b	2.20	8
37	cyc 116	2.08	7
38	enzastaurin	2.08	7
39	tg100 115	2.08	7
40	rg 547	2.08	7
41	amg 900	2.08	7
42	gsk 1059615	1.95	6
43	sra 737	1.95	6
44	sel 120 free base	1.95	6
45	demethylbellidifolin	1.95	6
46	t3 clk	1.79	5
47	lorecivivint	1.79	5
48	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	1.61	4
49	sp600125	1.39	3
50	egcg	0.69	1

Showing top 50 of 52 compounds. Use the BiohacksAI search to explore all CLK2 modulators.

About CLK2 as a Drug Target

CLK2 (CDC like kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 52 compounds with documented CLK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CLK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.