What compounds target CLK3?

BiohacksAI has identified 32 compounds that interact with CLK3 (CDC like kinase 3). Top compounds include: epigalocatechin gallate, alvocidib, pi 103, bosutinib, bi 2536. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CLK3 (CDC like kinase)?

CLK3 is CDC like kinase 3. It is a molecular target for 32 compounds documented in PubMed bioassay data. UniProt ID: P49761. NCBI Gene ID: 1198.

CLK3

MOLECULAR TARGET

CDC like kinase 3

UniProt: P49761 NCBI Gene: 119832 compounds

CLK3 (CDC like kinase 3) is targeted by 32 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CLK3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	epigalocatechin gallate	5.40	220
2	alvocidib	4.52	91
3	pi 103	4.17	64
4	bosutinib	4.08	58
5	bi 2536	4.01	54
6	midostaurin	3.85	46
7	silmitasertib	3.78	43
8	abemaciclib	3.66	38
9	pelitinib	3.50	32
10	tae 684	3.43	30
11	mln 8054	3.33	27
12	at 7519	3.33	27
13	tandutinib	3.22	24
14	alectinib	3.18	23
15	jnj 7706621	3.09	21
16	r 406	2.83	16
17	pha 665752	2.71	14
18	kw 2449	2.64	13
19	ast 487	2.56	12
20	rigosertib	2.30	9
21	tg100 115	2.08	7
22	rg 547	2.08	7
23	amg 900	2.08	7
24	demethylbellidifolin	1.95	6
25	t3 clk	1.79	5
26	lorecivivint	1.79	5
27	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	1.39	3
28	Quercetin	1.10	2
29	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
30	egcg	0.69	1
31	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	0.69	1
32	myricetin-3-O-galactopyranoside [Supplementary Concept]	0.69	1

About CLK3 as a Drug Target

CLK3 (CDC like kinase 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 32 compounds with documented CLK3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CLK3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.