What compounds target DHI1?

BiohacksAI has identified 69 compounds that interact with DHI1 (11-beta-hydroxysteroid dehydrogenase 1). Top compounds include: bdb merck 544 3 adamantan 1 yl 6 7 8 9 tetrahydro 5h 1 2 4 triazolo 4 3 a azepine ch, bdb chembl4748750, bdb chembl4746745, bdb chembl4747534, bdb chembl4779054. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is DHI1 (11-beta-hydroxysteroid dehydrogenase 1)?

DHI1 is 11-beta-hydroxysteroid dehydrogenase 1. It is a molecular target for 69 compounds documented in PubMed bioassay data.

DHI1

MOLECULAR TARGET

11-beta-hydroxysteroid dehydrogenase 1

69 compounds

DHI1 (11-beta-hydroxysteroid dehydrogenase 1) is targeted by 69 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting DHI1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	bdb merck 544 3 adamantan 1 yl 6 7 8 9 tetrahydro 5h 1 2 4 triazolo 4 3 a azepine ch	1.10	2
2	bdb chembl4748750	0.69	1
3	bdb chembl4746745	0.69	1
4	bdb chembl4747534	0.69	1
5	bdb chembl4779054	0.69	1
6	bdb chembl4788862	0.69	1
7	bdb r 3 3 cyano pyridin 2 ylamino pyrrolidine 1 carboxylic acid 5 carbamoyl adamanta	0.69	1
8	bdb r 3 5 cyano pyridin 2 ylamino pyrrolidine 1 carboxylic acid 5 carbamoyl adamanta	0.69	1
9	bdb r 3 6 trifluoromethyl pyridin 2 ylamino pyrrolidine 1 carboxylic acid 5 carbamoy	0.69	1
10	bdb r 3 3 trifluoromethyl pyridin 2 ylamino pyrrolidine 1 carboxylic acid 5 carbamoy	0.69	1
11	bdb r 3 5 trifluoromethyl pyridin 2 ylamino pyrrolidine 1 carboxylic acid 5 carbamoy	0.69	1
12	bdb s 3 3 trifluoromethyl pyridin 2 ylamino pyrrolidine 1 carboxylic acid 5 carbamoy	0.69	1
13	bdb 1 2 adamantyl 3 benzylpyrrolidin 2 one chembl218286	0.69	1
14	bdb 1 piperidin 1 yl cyclopropanecarboxylic acid 5 hydroxy adamantan 2 yl amide chem	0.69	1
15	bdb 1r 3r 4s 7s 4 2 2 chlorophenoxy 2 methylpropanamido adamantane 1 carboxylic acid	0.69	1
16	bdb 1r 3r 4s 7s 4 2 2 chlorophenoxy 2 methylpropanamido n methanesulfonyladamantane	0.69	1
17	bdb 1r 3r 4s 7s 4 2 3 chlorophenoxy 2 methylpropanamido adamantane 1 carboxylic acid	0.69	1
18	bdb 1r 3r 4s 7s 4 2 4 chlorophenoxy 2 methylpropanamido n pyridin 4 ylmethyl adamant	0.69	1
19	bdb 2 1 adamantan 2 yl carbamoyl 2 3 dihydrospiro indene 1 4 piperidine 3 yl acetic	0.69	1
20	bdb 2 1 adamantan 2 yl carbamoyl 4 methyl 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
21	bdb 2 1 adamantan 2 yl carbamoyl 5 chloro 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
22	bdb 2 1 adamantan 2 yl carbamoyl 5 methyl 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
23	bdb 2 1 adamantan 2 yl carbamoyl 6 chloro 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
24	bdb 2 1 adamantan 2 yl carbamoyl 6 methyl 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
25	bdb 2 1 adamantan 2 yl carbamoyl 7 bromo 2 3 dihydrospiro indene 1 4 piperidine 3 yl	0.69	1
26	bdb 2 1 adamantan 2 yl carbamoyl 7 chloro 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
27	bdb 2 1 adamantan 2 yl carbamoyl 7 methyl 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
28	bdb 2 2 6 dichloro 4 fluoro phenoxy 2 methyl n 5 sulfamoyl adamantan 2 yl propionami	0.69	1
29	bdb 2 2 chloro 4 fluorophenoxy 2 methyl n 1r 2s 5r 7s 5 1h 1 2 3 4 tetrazol 5 yl ada	0.69	1
30	bdb 2 2 chloro phenoxy 2 methyl n 5 sulfamoyl adamantan 2 yl propionamide chembl2393	0.69	1
31	bdb 2 2 chloro phenoxy n 5 methanesulfonyl adamantan 2 yl 2 methyl propionamide chem	0.69	1
32	bdb 2 3 chloro phenoxy 2 methyl n 5 sulfamoyl adamantan 2 yl propionamide chembl3991	0.69	1
33	bdb 2 3r 1 adamantan 2 yl carbamoyl 7 bromo 2 3 dihydrospiro indene 1 4 piperidine 3	0.69	1
34	bdb 2 3s 1 adamantan 2 yl carbamoyl 7 bromo 2 3 dihydrospiro indene 1 4 piperidine 3	0.69	1
35	bdb 2 hexahydro 2 5 methanopentalen 3a 1h ylamino 1 thia 3 azaspiro 4 4 non 2 en 4 o	0.69	1
36	bdb 3 3 dimethyl 1 5 1h tetrazol 5 yl adamantan 2 yl 4 5 trifluoromethyl pyridin 2 y	0.69	1
37	bdb 3 3 dimethyl pentanedioic acid 5 carbamoyl adamantan 2 yl amide cyclopropylamide	0.69	1
38	bdb 3 3 dimethyl pentanedioic acid cyclopropylamide 5 hydroxy adamantan 2 yl amide c	0.69	1
39	bdb 3 adamantan 1 yl 5 6 7 8 9 10 hexahydro 1 2 4 triazolo 4 3 a azocine chembl25677	0.69	1
40	bdb 3 benzyl 1 5 hydroxy adamantan 2 yl pyrrolidin 2 one chembl376306	0.69	1
41	bdb 3 phenyl adamantan 1 yl piperidin 1 yl methanone chembl1088379	0.69	1
42	bdb 4 1 4 5 trifluoromethyl pyridin 2 yl piperazin 1 yl cyclopropanecarbonyl amino a	0.69	1
43	bdb 4 2 3 3 difluoro piperidin 1 yl butyrylamino adamantane 1 carboxylic acid amide	0.69	1
44	bdb 4 2 methyl 2 4 5 trifluoromethyl pyridin 2 yl piperazin 1 yl propionylamino adam	0.69	1
45	bdb 4 3 3 dimethyl 2 oxo 4 4 1 2 4 triazol 1 yl phenoxymethyl pyrrolidin 1 yl adaman	0.69	1
46	bdb 4 4 4 imidazol 1 yl phenoxymethyl 3 3 dimethyl 2 oxo pyrrolidin 1 yl adamantane	0.69	1
47	bdb 4 amino 3 5 dichloro phenyl 2 aza tricyclo 3 3 1 1 3 7 dec 2 yl methanone chembl	0.69	1
48	bdb 5 5 diethyl 2 tricyclo 3 3 1 0 3 7 nonan 3 ylamino 4 5 dihydro 1 3 thiazol 4 one	0.69	1
49	bdb 5 ethyl 5 methyl 2 tricyclo 3 3 1 0 3 7 nonan 3 ylamino 4 5 dihydro 1 3 thiazol	0.69	1
50	bdb chembl2152223	0.69	1

Showing top 50 of 69 compounds. Use the BiohacksAI search to explore all DHI1 modulators.

About DHI1 as a Drug Target

DHI1 (11-beta-hydroxysteroid dehydrogenase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 69 compounds with documented DHI1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

DHI1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.