What compounds target DHI2?

BiohacksAI has identified 58 compounds that interact with DHI2 (11-beta-hydroxysteroid dehydrogenase type 2). Top compounds include: bdb merck 544 3 adamantan 1 yl 6 7 8 9 tetrahydro 5h 1 2 4 triazolo 4 3 a azepine ch, bdb chembl4748750, bdb r 3 3 cyano pyridin 2 ylamino pyrrolidine 1 carboxylic acid 5 carbamoyl adamanta, bdb r 3 5 cyano pyridin 2 ylamino pyrrolidine 1 carboxylic acid 5 carbamoyl adamanta, bdb 1 2 adamantyl 3 benzylpyrrolidin 2 one chembl218286. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is DHI2 (11-beta-hydroxysteroid dehydrogenase type)?

DHI2 is 11-beta-hydroxysteroid dehydrogenase type 2. It is a molecular target for 58 compounds documented in PubMed bioassay data.

DHI2

MOLECULAR TARGET

11-beta-hydroxysteroid dehydrogenase type 2

58 compounds

DHI2 (11-beta-hydroxysteroid dehydrogenase type 2) is targeted by 58 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting DHI2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	bdb merck 544 3 adamantan 1 yl 6 7 8 9 tetrahydro 5h 1 2 4 triazolo 4 3 a azepine ch	1.10	2
2	bdb chembl4748750	0.69	1
3	bdb r 3 3 cyano pyridin 2 ylamino pyrrolidine 1 carboxylic acid 5 carbamoyl adamanta	0.69	1
4	bdb r 3 5 cyano pyridin 2 ylamino pyrrolidine 1 carboxylic acid 5 carbamoyl adamanta	0.69	1
5	bdb 1 2 adamantyl 3 benzylpyrrolidin 2 one chembl218286	0.69	1
6	bdb 1 piperidin 1 yl cyclopropanecarboxylic acid 5 hydroxy adamantan 2 yl amide chem	0.69	1
7	bdb 1r 3r 4s 7s 4 2 2 chlorophenoxy 2 methylpropanamido adamantane 1 carboxylic acid	0.69	1
8	bdb 1r 3r 4s 7s 4 2 2 chlorophenoxy 2 methylpropanamido n methanesulfonyladamantane	0.69	1
9	bdb 1r 3r 4s 7s 4 2 3 chlorophenoxy 2 methylpropanamido adamantane 1 carboxylic acid	0.69	1
10	bdb 1r 3r 4s 7s 4 2 4 chlorophenoxy 2 methylpropanamido n pyridin 4 ylmethyl adamant	0.69	1
11	bdb 2 1 adamantan 2 yl carbamoyl 2 3 dihydrospiro indene 1 4 piperidine 3 yl acetic	0.69	1
12	bdb 2 1 adamantan 2 yl carbamoyl 4 methyl 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
13	bdb 2 1 adamantan 2 yl carbamoyl 5 chloro 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
14	bdb 2 1 adamantan 2 yl carbamoyl 5 methyl 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
15	bdb 2 1 adamantan 2 yl carbamoyl 6 chloro 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
16	bdb 2 1 adamantan 2 yl carbamoyl 6 methyl 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
17	bdb 2 1 adamantan 2 yl carbamoyl 7 bromo 2 3 dihydrospiro indene 1 4 piperidine 3 yl	0.69	1
18	bdb 2 1 adamantan 2 yl carbamoyl 7 chloro 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
19	bdb 2 1 adamantan 2 yl carbamoyl 7 methyl 2 3 dihydrospiro indene 1 4 piperidine 3 y	0.69	1
20	bdb 2 2 6 dichloro 4 fluoro phenoxy 2 methyl n 5 sulfamoyl adamantan 2 yl propionami	0.69	1
21	bdb 2 2 chloro 4 fluorophenoxy 2 methyl n 1r 2s 5r 7s 5 1h 1 2 3 4 tetrazol 5 yl ada	0.69	1
22	bdb 2 2 chloro phenoxy 2 methyl n 5 sulfamoyl adamantan 2 yl propionamide chembl2393	0.69	1
23	bdb 2 2 chloro phenoxy n 5 methanesulfonyl adamantan 2 yl 2 methyl propionamide chem	0.69	1
24	bdb 2 3 chloro phenoxy 2 methyl n 5 sulfamoyl adamantan 2 yl propionamide chembl3991	0.69	1
25	bdb 2 3r 1 adamantan 2 yl carbamoyl 7 bromo 2 3 dihydrospiro indene 1 4 piperidine 3	0.69	1
26	bdb 2 3s 1 adamantan 2 yl carbamoyl 7 bromo 2 3 dihydrospiro indene 1 4 piperidine 3	0.69	1
27	bdb 2 hexahydro 2 5 methanopentalen 3a 1h ylamino 1 thia 3 azaspiro 4 4 non 2 en 4 o	0.69	1
28	bdb 3 3 dimethyl 1 5 1h tetrazol 5 yl adamantan 2 yl 4 5 trifluoromethyl pyridin 2 y	0.69	1
29	bdb 3 3 dimethyl pentanedioic acid 5 carbamoyl adamantan 2 yl amide cyclopropylamide	0.69	1
30	bdb 3 3 dimethyl pentanedioic acid cyclopropylamide 5 hydroxy adamantan 2 yl amide c	0.69	1
31	bdb 3 adamantan 1 yl 5 6 7 8 9 10 hexahydro 1 2 4 triazolo 4 3 a azocine chembl25677	0.69	1
32	bdb 3 benzyl 1 5 hydroxy adamantan 2 yl pyrrolidin 2 one chembl376306	0.69	1
33	bdb 3 phenyl adamantan 1 yl piperidin 1 yl methanone chembl1088379	0.69	1
34	bdb 4 1 4 5 trifluoromethyl pyridin 2 yl piperazin 1 yl cyclopropanecarbonyl amino a	0.69	1
35	bdb 4 2 3 3 difluoro piperidin 1 yl butyrylamino adamantane 1 carboxylic acid amide	0.69	1
36	bdb 4 2 methyl 2 4 5 trifluoromethyl pyridin 2 yl piperazin 1 yl propionylamino adam	0.69	1
37	bdb 4 3 3 dimethyl 2 oxo 4 4 1 2 4 triazol 1 yl phenoxymethyl pyrrolidin 1 yl adaman	0.69	1
38	bdb 4 4 4 imidazol 1 yl phenoxymethyl 3 3 dimethyl 2 oxo pyrrolidin 1 yl adamantane	0.69	1
39	bdb 4 amino 3 5 dichloro phenyl 2 aza tricyclo 3 3 1 1 3 7 dec 2 yl methanone chembl	0.69	1
40	bdb 5 5 diethyl 2 tricyclo 3 3 1 0 3 7 nonan 3 ylamino 4 5 dihydro 1 3 thiazol 4 one	0.69	1
41	bdb 5 ethyl 5 methyl 2 tricyclo 3 3 1 0 3 7 nonan 3 ylamino 4 5 dihydro 1 3 thiazol	0.69	1
42	bdb chembl2152223	0.69	1
43	bdb chembl2152237	0.69	1
44	bdb chembl2380648	0.69	1
45	bdb chembl3401671	0.69	1
46	bdb chembl3401681	0.69	1
47	bdb chembl3401685	0.69	1
48	bdb chembl4160328	0.69	1
49	bdb chembl4162610	0.69	1
50	bdb chembl4163698	0.69	1

Showing top 50 of 58 compounds. Use the BiohacksAI search to explore all DHI2 modulators.

About DHI2 as a Drug Target

DHI2 (11-beta-hydroxysteroid dehydrogenase type 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 58 compounds with documented DHI2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

DHI2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.