What compounds target JAK1?

BiohacksAI has identified 59 compounds that interact with JAK1 (Tyrosine-protein kinase JAK1). Top compounds include: tofacitinib, tozasertib, ponatinib, ruxolitinib, ceritinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is JAK1 (Tyrosine-protein kinase JAK1)?

JAK1 is Tyrosine-protein kinase JAK1. It is a molecular target for 59 compounds documented in PubMed bioassay data.

JAK1

MOLECULAR TARGET

Tyrosine-protein kinase JAK1

59 compounds

JAK1 (Tyrosine-protein kinase JAK1) is targeted by 59 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting JAK1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	tofacitinib	4.65	104
2	tozasertib	4.33	75
3	ponatinib	4.26	70
4	ruxolitinib	4.23	68
5	ceritinib	4.19	65
6	pi 103	4.17	64
7	midostaurin	3.85	46
8	nintedanib	3.61	36
9	baricitinib	3.56	34
10	tae 684	3.43	30
11	fedratinib	3.40	29
12	entrectinib	3.18	23
13	dovitinib	3.09	21
14	jnj 7706621	3.09	21
15	at 9283	3.09	21
16	upadacitinib	3.09	21
17	lestaurtinib	3.04	20
18	pacritinib	3.04	20
19	filgotinib	3.04	20
20	momelotinib	2.89	17
21	r 406	2.83	16
22	sotrastaurin	2.77	15
23	ritlecitinib	2.77	15
24	pha 665752	2.71	14
25	apitolisib	2.71	14
26	kw 2449	2.64	13
27	ast 487	2.56	12
28	zotiraciclib	2.56	12
29	motesanib	2.48	11
30	deucravacitinib	2.48	11
31	azd 1480	2.30	9
32	reversine	2.30	9
33	vs 5584	2.30	9
34	su 014813	2.20	8
35	rebastinib	2.20	8
36	decernotinib	2.20	8
37	gandotinib	2.20	8
38	cyc 116	2.08	7
39	tg100 115	2.08	7
40	cerdulatinib	1.95	6
41	itacitinib	1.95	6
42	delgocitinib	1.95	6
43	pf 03814735	1.79	5
44	abrocitinib	1.79	5
45	bdb pf 06651600 us11111242 example 5 us9617258 example 5	0.69	1
46	bdb asp 015k asp015k peficitinib	0.69	1
47	bdb chembl4238926	0.69	1
48	bdb chembl4446102	0.69	1
49	bdb e z 2 cyano n n dimethyl 3 5 1 1s 2r 2 methylcyclohexyl 1 6 dihydroimidazo 4 5 d	0.69	1
50	bdb pf 02384554 us10966980 example 8 us9035074 8	0.69	1

Showing top 50 of 59 compounds. Use the BiohacksAI search to explore all JAK1 modulators.

About JAK1 as a Drug Target

JAK1 (Tyrosine-protein kinase JAK1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 59 compounds with documented JAK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

JAK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.