What compounds target MAP3K19?

BiohacksAI has identified 43 compounds that interact with MAP3K19 (mitogen-activated protein kinase kinase kinase 19). Top compounds include: gefitinib, erlotinib, foretinib, tozasertib, vandetanib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MAP3K19 (mitogen-activated protein kinase)?

MAP3K19 is mitogen-activated protein kinase kinase kinase 19. It is a molecular target for 43 compounds documented in PubMed bioassay data. UniProt ID: Q56UN5. NCBI Gene ID: 80122.

MAP3K19

MOLECULAR TARGET

mitogen-activated protein kinase kinase kinase 19

UniProt: Q56UN5 NCBI Gene: 8012243 compounds

MAP3K19 (mitogen-activated protein kinase kinase kinase 19) is targeted by 43 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MAP3K19

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	vandetanib	4.30	73
6	ruxolitinib	4.23	68
7	pi 103	4.17	64
8	bosutinib	4.08	58
9	bi 2536	4.01	54
10	quizartinib	3.99	53
11	midostaurin	3.85	46
12	pazopanib	3.69	39
13	vatalanib	3.69	39
14	neratinib	3.66	38
15	nintedanib	3.61	36
16	canertinib	3.53	33
17	tae 684	3.43	30
18	fedratinib	3.40	29
19	linifanib	3.33	27
20	tandutinib	3.22	24
21	dovitinib	3.09	21
22	lestaurtinib	3.04	20
23	ruboxistaurin	2.94	18
24	defosbarasertib	2.89	17
25	r 406	2.83	16
26	cediranib	2.83	16
27	pha 665752	2.71	14
28	bms 345541	2.71	14
29	kw 2449	2.64	13
30	gsk 690693	2.64	13
31	ast 487	2.56	12
32	raf 265	2.48	11
33	motesanib	2.48	11
34	brivanib	2.48	11
35	gsk 461364	2.40	10
36	sgx 523	2.30	9
37	su 014813	2.20	8
38	enzastaurin	2.08	7
39	tg100 115	2.08	7
40	Sorafenib	1.10	2
41	Axitinib	0.69	1
42	Crizotinib	0.69	1
43	pictilisib	0.69	1

About MAP3K19 as a Drug Target

MAP3K19 (mitogen-activated protein kinase kinase kinase 19) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 43 compounds with documented MAP3K19 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MAP3K19 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.