What compounds target MAP3K20?

BiohacksAI has identified 46 compounds that interact with MAP3K20 (mitogen-activated protein kinase kinase kinase 20). Top compounds include: imatinib, sb 203580, ibrutinib, foretinib, tozasertib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MAP3K20 (mitogen-activated protein kinase)?

MAP3K20 is mitogen-activated protein kinase kinase kinase 20. It is a molecular target for 46 compounds documented in PubMed bioassay data. NCBI Gene ID: 51776.

MAP3K20

MOLECULAR TARGET

mitogen-activated protein kinase kinase kinase 20

NCBI Gene: 5177646 compounds

MAP3K20 (mitogen-activated protein kinase kinase kinase 20) is targeted by 46 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MAP3K20

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	imatinib	5.47	236
2	sb 203580	4.92	136
3	ibrutinib	4.86	128
4	foretinib	4.34	76
5	tozasertib	4.33	75
6	vandetanib	4.30	73
7	ponatinib	4.26	70
8	nilotinib	4.17	64
9	bosutinib	4.08	58
10	doramapimod	4.06	57
11	quizartinib	3.99	53
12	vatalanib	3.69	39
13	neratinib	3.66	38
14	regorafenib	3.56	34
15	canertinib	3.53	33
16	pelitinib	3.50	32
17	fedratinib	3.40	29
18	saracatinib	3.33	27
19	dabrafenib	3.30	26
20	gw305074x	3.14	22
21	dasatinib anhydrous	3.09	21
22	lestaurtinib	3.04	20
23	pacritinib	3.04	20
24	defosbarasertib	2.89	17
25	masitinib	2.77	15
26	plx 4720	2.71	14
27	kw 2449	2.64	13
28	ast 487	2.56	12
29	raf 265	2.48	11
30	motesanib	2.48	11
31	aee 788	2.30	9
32	rebastinib	2.20	8
33	golvatinib	2.20	8
34	encorafenib	2.20	8
35	cyc 116	2.08	7
36	ly 3009120	2.08	7
37	osi 930	2.08	7
38	Sorafenib	1.95	6
39	cep 32496	1.95	6
40	bafetinib	1.95	6
41	rivoceranib	1.95	6
42	Vemurafenib	1.61	4
43	Axitinib	1.10	2
44	Dasatinib	1.10	2
45	alsterpaullone	0.69	1
46	sp600125	0.69	1

About MAP3K20 as a Drug Target

MAP3K20 (mitogen-activated protein kinase kinase kinase 20) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 46 compounds with documented MAP3K20 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MAP3K20 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.