What compounds target MAP4K1?

BiohacksAI has identified 40 compounds that interact with MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1). Top compounds include: alvocidib, foretinib, tozasertib, vandetanib, ponatinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MAP4K1 (Mitogen-activated protein kinase)?

MAP4K1 is Mitogen-activated protein kinase kinase kinase kinase 1. It is a molecular target for 40 compounds documented in PubMed bioassay data.

MAP4K1

MOLECULAR TARGET

Mitogen-activated protein kinase kinase kinase kinase 1

40 compounds

MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1) is targeted by 40 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MAP4K1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	alvocidib	4.52	91
2	foretinib	4.34	76
3	tozasertib	4.33	75
4	vandetanib	4.30	73
5	ponatinib	4.26	70
6	nilotinib	4.17	64
7	bosutinib	4.08	58
8	midostaurin	3.85	46
9	pazopanib	3.69	39
10	neratinib	3.66	38
11	nintedanib	3.61	36
12	pelitinib	3.50	32
13	tae 684	3.43	30
14	fedratinib	3.40	29
15	gilteritinib	3.40	29
16	linifanib	3.33	27
17	bisindolylmaleimide ix	3.14	22
18	dovitinib	3.09	21
19	jnj 7706621	3.09	21
20	at 9283	3.09	21
21	lestaurtinib	3.04	20
22	pacritinib	3.04	20
23	pf 03758309	3.00	19
24	ruboxistaurin	2.94	18
25	danusertib	2.94	18
26	orantinib	2.89	17
27	r 406	2.83	16
28	k 252a	2.83	16
29	cediranib	2.83	16
30	milciclib	2.77	15
31	pf 00562271	2.77	15
32	pha 665752	2.71	14
33	kw 2449	2.64	13
34	ast 487	2.56	12
35	defactinib	2.48	11
36	motesanib	2.48	11
37	azd 7762	2.30	9
38	su 014813	2.20	8
39	rebastinib	2.20	8
40	enzastaurin	2.08	7

About MAP4K1 as a Drug Target

MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 40 compounds with documented MAP4K1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MAP4K1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.