What compounds target MAP4K5?

BiohacksAI has identified 57 compounds that interact with MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5). Top compounds include: foretinib, tozasertib, vandetanib, bosutinib, quizartinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MAP4K5 (mitogen-activated protein kinase)?

MAP4K5 is mitogen-activated protein kinase kinase kinase kinase 5. It is a molecular target for 57 compounds documented in PubMed bioassay data. NCBI Gene ID: 11183.

MAP4K5

MOLECULAR TARGET

mitogen-activated protein kinase kinase kinase kinase 5

NCBI Gene: 1118357 compounds

MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5) is targeted by 57 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MAP4K5

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	foretinib	4.34	76
2	tozasertib	4.33	75
3	vandetanib	4.30	73
4	bosutinib	4.08	58
5	quizartinib	3.99	53
6	midostaurin	3.85	46
7	pazopanib	3.69	39
8	neratinib	3.66	38
9	nintedanib	3.61	36
10	canertinib	3.53	33
11	pelitinib	3.50	32
12	tae 684	3.43	30
13	gilteritinib	3.40	29
14	linifanib	3.33	27
15	saracatinib	3.33	27
16	tandutinib	3.22	24
17	dovitinib	3.09	21
18	jnj 7706621	3.09	21
19	at 9283	3.09	21
20	lestaurtinib	3.04	20
21	lenvatinib	3.04	20
22	ruboxistaurin	2.94	18
23	danusertib	2.94	18
24	defosbarasertib	2.89	17
25	barasertib	2.89	17
26	k 252a	2.83	16
27	cediranib	2.83	16
28	imd 0354	2.83	16
29	milciclib	2.77	15
30	pha 665752	2.71	14
31	plx 4720	2.71	14
32	crenolanib	2.71	14
33	enmd 2076	2.71	14
34	kw 2449	2.64	13
35	linsitinib	2.64	13
36	ast 487	2.56	12
37	zotiraciclib	2.56	12
38	raf 265	2.48	11
39	brivanib	2.48	11
40	azd 7762	2.30	9
41	aee 788	2.30	9
42	su 014813	2.20	8
43	rebastinib	2.20	8
44	golvatinib	2.20	8
45	cyc 116	2.08	7
46	amg 900	2.08	7
47	ly 3009120	2.08	7
48	Sorafenib	1.95	6
49	cep 32496	1.95	6
50	pf 03814735	1.79	5

Showing top 50 of 57 compounds. Use the BiohacksAI search to explore all MAP4K5 modulators.

About MAP4K5 as a Drug Target

MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 57 compounds with documented MAP4K5 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MAP4K5 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.