NLRP3
MOLECULAR TARGETNLR family pyrin domain containing 3
NLRP3 (NLR family pyrin domain containing 3) is targeted by 21 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting NLRP3
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Androsterone | 1.61 | 4 |
| 2 | cycloheximide | 1.61 | 4 |
| 3 | Dimethyl Fumarate | 1.61 | 4 |
| 4 | Etiocholanolone | 1.61 | 4 |
| 5 | Hexachlorophene | 1.61 | 4 |
| 6 | Lithocholic Acid | 1.61 | 4 |
| 7 | Niclosamide | 1.61 | 4 |
| 8 | tyrphostin 9 | 1.61 | 4 |
| 9 | Calcitriol | 1.39 | 3 |
| 10 | Dihydrotestosterone | 1.39 | 3 |
| 11 | Ethinyl Estradiol | 1.39 | 3 |
| 12 | Thioridazine | 1.39 | 3 |
| 13 | 20-alpha-Dihydroprogesterone | 1.10 | 2 |
| 14 | Anisomycin | 1.10 | 2 |
| 15 | Chlorhexidine | 1.10 | 2 |
| 16 | oridonin | 1.10 | 2 |
| 17 | Tocainide | 1.10 | 2 |
| 18 | Bortezomib | 0.69 | 1 |
| 19 | Disulfiram | 0.69 | 1 |
| 20 | Glyburide | 0.69 | 1 |
| 21 | Riluzole | 0.69 | 1 |
About NLRP3 as a Drug Target
NLRP3 (NLR family pyrin domain containing 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 21 compounds with documented NLRP3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
NLRP3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.