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Calcitriol

The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.

300+ PubMed studies analyzed · 14 RCTs · Evidence Score: 43.6

Research Domains

Calcitriol has been studied across 23 research domains including 🦴 Bone & Joint, 🔬 Oncology, 🧬 Hormones, 🫘 Kidney, 🔬 Inflammation. The primary research focus is 🦴 Bone & Joint with 53% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Calcitriol, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

tretinoin
8 shared targets
alitretinoin
7 shared targets
bexarotene
6 shared targets
Rifaximin
8 shared targets
Ezetimibe
10 shared targets
Lumefantrine
8 shared targets
Simvastatin
12 shared targets
Tripterygium
10 shared targets
Canagliflozin
6 shared targets
Nisoldipine
15 shared targets
Loading evidence profile...

This evidence profile for Calcitriol is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.