What compounds target NUAK2?

BiohacksAI has identified 31 compounds that interact with NUAK2 (NUAK family kinase 2). Top compounds include: gefitinib, tofacitinib, alvocidib, tozasertib, ruxolitinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NUAK2 (NUAK family kinase)?

NUAK2 is NUAK family kinase 2. It is a molecular target for 31 compounds documented in PubMed bioassay data. UniProt ID: Q9H093. NCBI Gene ID: 81788.

NUAK2

MOLECULAR TARGET

NUAK family kinase 2

UniProt: Q9H093 NCBI Gene: 8178831 compounds

NUAK2 (NUAK family kinase 2) is targeted by 31 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NUAK2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	tofacitinib	4.65	104
3	alvocidib	4.52	91
4	tozasertib	4.33	75
5	ruxolitinib	4.23	68
6	bosutinib	4.08	58
7	midostaurin	3.85	46
8	neratinib	3.66	38
9	nintedanib	3.61	36
10	pelitinib	3.50	32
11	bms 387032	3.47	31
12	tae 684	3.43	30
13	fedratinib	3.40	29
14	dovitinib	3.09	21
15	jnj 7706621	3.09	21
16	lestaurtinib	3.04	20
17	ruboxistaurin	2.94	18
18	danusertib	2.94	18
19	r 406	2.83	16
20	pha 665752	2.71	14
21	kw 2449	2.64	13
22	gsk 690693	2.64	13
23	defactinib	2.48	11
24	gsk 461364	2.40	10
25	bms 754807	2.30	9
26	su 014813	2.20	8
27	cyc 116	2.08	7
28	enzastaurin	2.08	7
29	pf 03814735	1.79	5
30	Axitinib	0.69	1
31	Crizotinib	0.69	1

About NUAK2 as a Drug Target

NUAK2 (NUAK family kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 31 compounds with documented NUAK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NUAK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.