What compounds target OPRK?

BiohacksAI has identified 270 compounds that interact with OPRK (Kappa-type opioid receptor). Top compounds include: bdb chebi 3216 buprenorphine, bdb naltrindole 8r 7 cyclopropylmethyl 5 6 7 8 14 14b hexahydro 4 8 methano 1 benzof, bdb naloxone nsc 10064 cas 465 65 6 naloxone, bdb nsc 223652 cas 29485 83 4 codeine codeine sulfate, bdb nsc 61677 cas 61677 etorphine hci. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is OPRK (Kappa-type opioid receptor)?

OPRK is Kappa-type opioid receptor. It is a molecular target for 270 compounds documented in PubMed bioassay data.

OPRK

MOLECULAR TARGET

Kappa-type opioid receptor

270 compounds

OPRK (Kappa-type opioid receptor) is targeted by 270 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting OPRK

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	bdb chebi 3216 buprenorphine	1.95	6
2	bdb naltrindole 8r 7 cyclopropylmethyl 5 6 7 8 14 14b hexahydro 4 8 methano 1 benzof	1.61	4
3	bdb naloxone nsc 10064 cas 465 65 6 naloxone	1.39	3
4	bdb nsc 223652 cas 29485 83 4 codeine codeine sulfate	1.39	3
5	bdb nsc 61677 cas 61677 etorphine hci	1.39	3
6	bdb cas 105618 26 6 nsc 3034416 nor bni	1.10	2
7	bdb buprenorphine buprenorphine2 3 cyclopropylmethyl 11 hydroxy 15 methoxy 13 oxa 3	1.10	2
8	bdb cas 115077 nsc 115077 win 44 441	1.10	2
9	bdb cas 27943 naltrexone hcl nsc 27943 naltrexone	1.10	2
10	bdb chembl2113666	1.10	2
11	bdb chembl2397015	1.10	2
12	bdb chembl2397016	1.10	2
13	bdb chembl2397017	1.10	2
14	bdb chembl2397018	1.10	2
15	bdb chembl2397019	1.10	2
16	bdb chembl2397020	1.10	2
17	bdb chembl2397021	1.10	2
18	bdb chembl2397022	1.10	2
19	bdb chembl3759092	1.10	2
20	bdb chembl378753 nalbzoh	1.10	2
21	bdb mcl 183 chembl390866	1.10	2
22	bdb 1n 10 hydroxy 4 methyl 14 oxo 13r 17s 12 oxa 4 azapentacyclo 9 6 1 01 13 05 17 0	1.10	2
23	bdb chembl516641 hyperforin	0.69	1
24	bdb chembl2205836	0.69	1
25	bdb chembl2205811	0.69	1
26	bdb chembl2205812	0.69	1
27	bdb chembl2205813	0.69	1
28	bdb chembl2205823	0.69	1
29	bdb chembl2205825	0.69	1
30	bdb chembl1189234 chembl538300 11 benzyl 11 azahexacyclo 5 4 1 02 6 03 10 04 8 09 12	0.69	1
31	bdb chembl3360829	0.69	1
32	bdb chembl3262088	0.69	1
33	bdb chembl3262089 us9480684 7a r ph bu127 us9259422 7a r ph bu127	0.69	1
34	bdb chembl3262091	0.69	1
35	bdb chembl3262361	0.69	1
36	bdb chembl3262362	0.69	1
37	bdb chembl3309515	0.69	1
38	bdb chembl3309518	0.69	1
39	bdb chembl4062717 us10377763 example 34	0.69	1
40	bdb chembl4066535	0.69	1
41	bdb chembl4071362	0.69	1
42	bdb chembl4080914	0.69	1
43	bdb chembl4846243	0.69	1
44	bdb chembl4871880	0.69	1
45	bdb 1 1 6 6 dimethyl bicyclo 3 1 1 hept 2 ylmethyl piperidin 4 yl 1 3 dihydro indol	0.69	1
46	bdb 1 adamantan 1 yl 3 2 2 amino 3 4 hydroxy 2 6 dimethyl phenyl propionyl 1 2 3 4 t	0.69	1
47	bdb 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epoxy 6 beta d glucopyranosyl	0.69	1
48	bdb 1s 9r 10r 5 amino 20 cyclobutylmethyl 6 thia 4 20 diazapentacyclo 8 7 3 0 1 9 0	0.69	1
49	bdb 1s 9r 10r 5 amino 20 cyclopropylmethyl 6 thia 4 20 diazapentacyclo 8 7 3 0 1 9 0	0.69	1
50	bdb 2 3 furylmethyl 5 9 diethyl 2 39 hydroxy 6 7 benzomorphan cas 56649 76 4 mr2266	0.69	1

Showing top 50 of 270 compounds. Use the BiohacksAI search to explore all OPRK modulators.

About OPRK as a Drug Target

OPRK (Kappa-type opioid receptor) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 270 compounds with documented OPRK interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

OPRK inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.