What compounds target OPRX?

BiohacksAI has identified 46 compounds that interact with OPRX (Nociceptin receptor). Top compounds include: bdb chebi 3216 buprenorphine, bdb chembl3262088, bdb chembl3262089 us9480684 7a r ph bu127 us9259422 7a r ph bu127, bdb chembl3262091, bdb chembl3262361. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is OPRX (Nociceptin receptor)?

OPRX is Nociceptin receptor. It is a molecular target for 46 compounds documented in PubMed bioassay data.

OPRX

MOLECULAR TARGET

Nociceptin receptor

46 compounds

OPRX (Nociceptin receptor) is targeted by 46 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting OPRX

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	bdb chebi 3216 buprenorphine	1.95	6
2	bdb chembl3262088	0.69	1
3	bdb chembl3262089 us9480684 7a r ph bu127 us9259422 7a r ph bu127	0.69	1
4	bdb chembl3262091	0.69	1
5	bdb chembl3262361	0.69	1
6	bdb chembl3262362	0.69	1
7	bdb chembl3309515	0.69	1
8	bdb chembl3309518	0.69	1
9	bdb 1 1 6 6 dimethyl bicyclo 3 1 1 hept 2 ylmethyl piperidin 4 yl 1 3 dihydro indol	0.69	1
10	bdb 2 exo 8 bis 2 chlorophenyl methyl 8 azabicyclo 3 2 1 oct 3 yl 1 piperidineaceton	0.69	1
11	bdb 3 1 benzylpyrrolidin 2 yl 8 2 chloro 4 methylphenyl 2 chlorophenyl methyl 8 azab	0.69	1
12	bdb 3 bis 2 chlorophenyl methyl 8 4 methylpyridin 2 yl 3 azabicyclo 3 2 1 octan 8 ol	0.69	1
13	bdb 3 bis 2 chlorophenyl methyl 8 pyridin 3 yl 3 azabicyclo 3 2 1 octan 8 ol chembl5	0.69	1
14	bdb 8 2 chloro 4 methylphenyl 2 chlorophenyl methyl 3 3 fluorophenyl 8 azabicyclo 3	0.69	1
15	bdb 8 2 chloro 4 methylphenyl 2 chlorophenyl methyl 3 3 hydroxypropyl 8 azabicyclo 3	0.69	1
16	bdb 8 2 chloro 4 methylphenyl 2 chlorophenyl methyl 3 cyclopentyl 8 azabicyclo 3 2 1	0.69	1
17	bdb 8 2 chloro 4 methylphenyl 2 chlorophenyl methyl 3 pyrimidin 4 yl 8 azabicyclo 3	0.69	1
18	bdb 8 bis 2 chlorophenyl methyl 3 phenyl 3 1h 1 2 4 triazol 3 yl 8 azabicyclo 3 2 1	0.69	1
19	bdb 8 dio tolylmethyl 3 phenyl 8 azabicyclo 3 2 1 octan 3 ol chembl513136	0.69	1
20	bdb 9 benzhydryl 3 phenyl 9 azabicyclo 3 3 1 nonan 3 ol chembl466846	0.69	1
21	bdb chembl1834413	0.69	1
22	bdb chembl3262372 us9480684 7a r 2 thienyl bu08026 us9259422 7a r 2 thienyl bu08026	0.69	1
23	bdb chembl3262377	0.69	1
24	bdb chembl3581751	0.69	1
25	bdb chembl3581752	0.69	1
26	bdb chembl3581753	0.69	1
27	bdb chembl3581754	0.69	1
28	bdb chembl3581756	0.69	1
29	bdb chembl3581757	0.69	1
30	bdb chembl3581762	0.69	1
31	bdb chembl4474536	0.69	1
32	bdb chembl4585935	0.69	1
33	bdb rel 1s 5s 8 bis 2 chlorophenyl methyl 8 azaspiro bicyclo 3 2 1 octane 3 3 indoli	0.69	1
34	bdb rel 8 bis 2 chlorophenyl methyl 3 phenyl 3 pyrrolidin 1 ylmethyl 8 aza bicyclo 3	0.69	1
35	bdb rel 8 bis 2 chlorophenyl methyl 3 phenyl 8 aza bicyclo 3 2 1 octan 3 yl n methyl	0.69	1
36	bdb rel 8 bis 2 chlorophenyl methyl 3 phenyl 8 aza bicyclo 3 2 1 octan 3 yl n n dime	0.69	1
37	bdb rel 8 bis 2 chlorophenyl methyl 3 phenyl 8 azabicyclo 3 2 1 octan 3 yl methanami	0.69	1
38	bdb rel methyl 8 bis 2 chlorophenyl methyl 3 phenyl 8 aza bicyclo 3 2 1 octan 3 yl m	0.69	1
39	bdb rel n 8 bis 2 chlorophenyl methyl 3 4 fluorophenyl 8 aza bicyclo 3 2 1 octan 3 y	0.69	1
40	bdb rel n 8 bis 2 chlorophenyl methyl 3 4 methoxyphenyl 8 aza bicyclo 3 2 1 octan 3	0.69	1
41	bdb rel n 8 bis 2 chlorophenyl methyl 3 6 fluoropyridin 2 yl 8 aza bicyclo 3 2 1 oct	0.69	1
42	bdb rel n 8 bis 2 chlorophenyl methyl 3 phenyl 8 aza bicyclo 3 2 1 octan 3 yl methyl	0.69	1
43	bdb us9480684 22 r 3 meph bu10112 chembl3581741 us9259422 22 r 3 meph bu10112	0.69	1
44	bdb us9480684 22 r 4 fph bu10120 chembl3581743 us9259422 22 r 4 fph bu10120	0.69	1
45	bdb us9480684 22 r ph bu128 chembl3581740 us9259422 22 r ph bu128	0.69	1
46	bdb us9480684 30 r ph bu10119 chembl3581750 us9259422 30 r ph bu10119	0.69	1

About OPRX as a Drug Target

OPRX (Nociceptin receptor) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 46 compounds with documented OPRX interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

OPRX inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.