What compounds target OX1R?

BiohacksAI has identified 34 compounds that interact with OX1R (Orexin/Hypocretin receptor type 1). Top compounds include: bdb chembl4062717 us10377763 example 34, bdb chembl4066535, bdb chembl4071362, bdb chembl4080914, bdb 1r 5r 2 7 fluoroquinazolin 2 yl 2 6 diazabicyclo 3 2 2 nonan 6 yl 5 methyl 2 2h . Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is OX1R (Orexin/Hypocretin receptor type)?

OX1R is Orexin/Hypocretin receptor type 1. It is a molecular target for 34 compounds documented in PubMed bioassay data.

OX1R

MOLECULAR TARGET

Orexin/Hypocretin receptor type 1

34 compounds

OX1R (Orexin/Hypocretin receptor type 1) is targeted by 34 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting OX1R

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	bdb chembl4062717 us10377763 example 34	0.69	1
2	bdb chembl4066535	0.69	1
3	bdb chembl4071362	0.69	1
4	bdb chembl4080914	0.69	1
5	bdb 1r 5r 2 7 fluoroquinazolin 2 yl 2 6 diazabicyclo 3 2 2 nonan 6 yl 5 methyl 2 2h	0.69	1
6	bdb 1r 5s 3 7 fluoroquinazolin 2 yl 3 6 diazabicyclo 3 2 2 nonan 6 yl 5 methyl 2 2h	0.69	1
7	bdb 1s 5r 3 7 fluoroquinazolin 2 yl 3 6 diazabicyclo 3 2 2 nonan 6 yl 5 methyl 2 2h	0.69	1
8	bdb 1s 5s 2 7 fluoroquinazolin 2 yl 2 6 diazabicyclo 3 2 2 nonan 6 yl 5 methyl 2 2h	0.69	1
9	bdb chembl3597967	0.69	1
10	bdb chembl3597968	0.69	1
11	bdb chembl4070275	0.69	1
12	bdb chembl4076262	0.69	1
13	bdb chembl4094071 us10377763 example 35	0.69	1
14	bdb chembl4098948	0.69	1
15	bdb chembl4203171	0.69	1
16	bdb chembl4208045	0.69	1
17	bdb chembl4213974	0.69	1
18	bdb chembl4215362	0.69	1
19	bdb chembl4442127	0.69	1
20	bdb chembl4448949	0.69	1
21	bdb chembl4454088	0.69	1
22	bdb chembl4456012	0.69	1
23	bdb chembl4457194	0.69	1
24	bdb chembl4467858	0.69	1
25	bdb chembl4588327	0.69	1
26	bdb r s 2 2h 1 2 3 triazol 2 yl phenyl 2 5 trifluoromethyl pyridin 2 yl oxy 7 azabic	0.69	1
27	bdb us9475819 11 us9062078 11 us9695183 12b us9062078 12b us9062078 12a us9637496 12	0.69	1
28	bdb us9475819 181	0.69	1
29	bdb us9475819 182 us9062078 181 us9695183 183b us9062078 182 us9062078 183a us906207	0.69	1
30	bdb us9475819 196 us9062078 196 us9695183 196 us9637496 196	0.69	1
31	bdb us9475819 211 us9062078 211 us9695183 211 us9637496 211	0.69	1
32	bdb us9475819 221 us9062078 221 us9695183 221 us9637496 221	0.69	1
33	bdb us9475819 30 us9062078 30 us9695183 30 us9637496 30	0.69	1
34	bdb us9475819 32 us9062078 32 us9695183 32 us9637496 32	0.69	1

About OX1R as a Drug Target

OX1R (Orexin/Hypocretin receptor type 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 34 compounds with documented OX1R interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

OX1R inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.