Question 1

What compounds target OX2R?

Accepted Answer

BiohacksAI has identified 30 compounds that interact with OX2R (Orexin receptor type 2). Top compounds include: bdb 1r 5r 2 7 fluoroquinazolin 2 yl 2 6 diazabicyclo 3 2 2 nonan 6 yl 5 methyl 2 2h , bdb 1r 5s 3 7 fluoroquinazolin 2 yl 3 6 diazabicyclo 3 2 2 nonan 6 yl 5 methyl 2 2h , bdb 1s 5r 3 7 fluoroquinazolin 2 yl 3 6 diazabicyclo 3 2 2 nonan 6 yl 5 methyl 2 2h , bdb 1s 5s 2 7 fluoroquinazolin 2 yl 2 6 diazabicyclo 3 2 2 nonan 6 yl 5 methyl 2 2h , bdb chembl3597967. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is OX2R (Orexin receptor type)?

Accepted Answer

OX2R is Orexin receptor type 2. It is a molecular target for 30 compounds documented in PubMed bioassay data.

#	Compound	Confidence	Active Assays
1	bdb 1r 5r 2 7 fluoroquinazolin 2 yl 2 6 diazabicyclo 3 2 2 nonan 6 yl 5 methyl 2 2h	0.69	1
2	bdb 1r 5s 3 7 fluoroquinazolin 2 yl 3 6 diazabicyclo 3 2 2 nonan 6 yl 5 methyl 2 2h	0.69	1
3	bdb 1s 5r 3 7 fluoroquinazolin 2 yl 3 6 diazabicyclo 3 2 2 nonan 6 yl 5 methyl 2 2h	0.69	1
4	bdb 1s 5s 2 7 fluoroquinazolin 2 yl 2 6 diazabicyclo 3 2 2 nonan 6 yl 5 methyl 2 2h	0.69	1
5	bdb chembl3597967	0.69	1
6	bdb chembl3597968	0.69	1
7	bdb chembl4070275	0.69	1
8	bdb chembl4076262	0.69	1
9	bdb chembl4094071 us10377763 example 35	0.69	1
10	bdb chembl4098948	0.69	1
11	bdb chembl4203171	0.69	1
12	bdb chembl4208045	0.69	1
13	bdb chembl4213974	0.69	1
14	bdb chembl4215362	0.69	1
15	bdb chembl4442127	0.69	1
16	bdb chembl4448949	0.69	1
17	bdb chembl4454088	0.69	1
18	bdb chembl4456012	0.69	1
19	bdb chembl4457194	0.69	1
20	bdb chembl4467858	0.69	1
21	bdb chembl4588327	0.69	1
22	bdb r s 2 2h 1 2 3 triazol 2 yl phenyl 2 5 trifluoromethyl pyridin 2 yl oxy 7 azabic	0.69	1
23	bdb us9475819 11 us9062078 11 us9695183 12b us9062078 12b us9062078 12a us9637496 12	0.69	1
24	bdb us9475819 181	0.69	1
25	bdb us9475819 182 us9062078 181 us9695183 183b us9062078 182 us9062078 183a us906207	0.69	1
26	bdb us9475819 196 us9062078 196 us9695183 196 us9637496 196	0.69	1
27	bdb us9475819 211 us9062078 211 us9695183 211 us9637496 211	0.69	1
28	bdb us9475819 221 us9062078 221 us9695183 221 us9637496 221	0.69	1
29	bdb us9475819 30 us9062078 30 us9695183 30 us9637496 30	0.69	1
30	bdb us9475819 32 us9062078 32 us9695183 32 us9637496 32	0.69	1

OX2R

Compounds Targeting OX2R

About OX2R as a Drug Target