What compounds target PIP4K2C?

BiohacksAI has identified 31 compounds that interact with PIP4K2C (Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma). Top compounds include: gefitinib, erlotinib, imatinib, osimertinib, alvocidib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

PIP4K2C

Q: What is PIP4K2C (Phosphatidylinositol 5-phosphate 4-kinase)?

PIP4K2C is Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma. It is a molecular target for 31 compounds documented in PubMed bioassay data.

MOLECULAR TARGET

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

31 compounds

PIP4K2C (Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma) is targeted by 31 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PIP4K2C

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	imatinib	5.47	236
4	osimertinib	5.03	152
5	alvocidib	4.52	91
6	cabozantinib	4.39	80
7	foretinib	4.34	76
8	palbociclib	4.22	67
9	nilotinib	4.17	64
10	pi 103	4.17	64
11	bi 2536	4.01	54
12	silmitasertib	3.78	43
13	pazopanib	3.69	39
14	tae 684	3.43	30
15	fedratinib	3.40	29
16	omipalisib	3.14	22
17	r 406	2.83	16
18	milciclib	2.77	15
19	jnj 38877605	2.71	14
20	linsitinib	2.64	13
21	gsk 461364	2.40	10
22	sgx 523	2.30	9
23	bgt 226 free base	2.20	8
24	cyc 116	2.08	7
25	tg100 115	2.08	7
26	mk 2461	2.08	7
27	fostamatinib	2.08	7
28	osi 027	2.08	7
29	bafetinib	1.95	6
30	gsk 1059615	1.95	6
31	icotinib	1.79	5

About PIP4K2C as a Drug Target

PIP4K2C (Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 31 compounds with documented PIP4K2C interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PIP4K2C inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.