PKM
MOLECULAR TARGETpyruvate kinase M1/2
PKM (pyruvate kinase M1/2) is targeted by 11 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting PKM
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Apigenin 5,7,4'-trihydroxy-flavone, | 1.39 | 3 |
| 2 | fisetin | 1.10 | 2 |
| 3 | myricetin-3-O-galactopyranoside [Supplementary Concept] | 1.10 | 2 |
| 4 | alphitonin [Supplementary Concept] from | 1.10 | 2 |
| 5 | Sirolimus | 0.69 | 1 |
| 6 | Spermidine | 0.69 | 1 |
| 7 | Catechin | 0.69 | 1 |
| 8 | Niclosamide | 0.69 | 1 |
| 9 | pd98059 | 0.69 | 1 |
| 10 | Pseudoephedrine | 0.69 | 1 |
| 11 | Suramin | 0.69 | 1 |
About PKM as a Drug Target
PKM (pyruvate kinase M1/2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 11 compounds with documented PKM interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
PKM inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.