What compounds target POLK?

BiohacksAI has identified 45 compounds that interact with POLK (DNA polymerase kappa). Top compounds include: myricetin-3-O-galactopyranoside [Supplementary Concept], Quercetin, Luteolin 5,7,3',4'-tetrahydroxy-flavone,, Ethidium, juglone hydroxylase [Supplementary Concept] catalyzes. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is POLK (DNA polymerase kappa)?

POLK is DNA polymerase kappa. It is a molecular target for 45 compounds documented in PubMed bioassay data. UniProt ID: Q9UBT6. NCBI Gene ID: 51426.

POLK

MOLECULAR TARGET

DNA polymerase kappa

UniProt: Q9UBT6 NCBI Gene: 5142645 compounds

POLK (DNA polymerase kappa) is targeted by 45 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting POLK

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	2.30	9
2	Quercetin	2.08	7
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	1.79	5
4	Ethidium	1.61	4
5	juglone hydroxylase [Supplementary Concept] catalyzes	1.61	4
6	alpha-Linolenic Acid	1.39	3
7	Carmine Coloring matter from	1.39	3
8	Epinephrine	1.39	3
9	gamma-Linolenic Acid	1.39	3
10	Levodopa	1.39	3
11	Masoprocol	1.39	3
12	piceatannol	1.39	3
13	Arachidonic Acid	1.10	2
14	fisetin	1.10	2
15	candesartan cilexetil [Supplementary Concept]	1.10	2
16	Cefixime	1.10	2
17	Daunorubicin	1.10	2
18	Diiodotyrosine	1.10	2
19	Idarubicin	1.10	2
20	Methyldopa	1.10	2
21	Norepinephrine Precursor of epinephrine that is secreted by	1.10	2
22	DEAD-box RNA Helicases	0.69	1
23	Thioctic Acid	0.69	1
24	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
25	Catechin	0.69	1
26	plumbagin [Supplementary Concept]	0.69	1
27	Resveratrol	0.69	1
28	Rutin	0.69	1
29	Ampicillin Semi-synthetic derivative of penicillin that functions as	0.69	1
30	Anthralin	0.69	1
31	Aurintricarboxylic Acid	0.69	1
32	butein	0.69	1
33	Cefotetan	0.69	1
34	Cimetidine	0.69	1
35	Demeclocycline	0.69	1
36	Dihydroxyphenylalanine	0.69	1
37	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	0.69	1
38	Catechin	0.69	1
39	Estramustine	0.69	1
40	o-Phthalaldehyde	0.69	1
41	Oxytetracycline	0.69	1
42	rafoxanide	0.69	1
43	streptonigrin	0.69	1
44	Suramin	0.69	1
45	Thioctic Acid	0.69	1

About POLK as a Drug Target

POLK (DNA polymerase kappa) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 45 compounds with documented POLK interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

POLK inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.