What compounds target PPP1R15A?

BiohacksAI has identified 30 compounds that interact with PPP1R15A (protein phosphatase 1, regulatory subunit 15A). Top compounds include: Azacitidine, Azacitidine, Carbazilquinone, cycloheximide, Ethidium. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PPP1R15A (protein phosphatase 1,)?

PPP1R15A is protein phosphatase 1, regulatory subunit 15A. It is a molecular target for 30 compounds documented in PubMed bioassay data. UniProt ID: Q6IN02. NCBI Gene ID: 171071.

PPP1R15A

MOLECULAR TARGET

protein phosphatase 1, regulatory subunit 15A

UniProt: Q6IN02 NCBI Gene: 17107130 compounds

PPP1R15A (protein phosphatase 1, regulatory subunit 15A) is targeted by 30 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PPP1R15A

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Azacitidine	1.39	3
2	Azacitidine	1.39	3
3	Carbazilquinone	1.39	3
4	cycloheximide	1.39	3
5	Ethidium	1.39	3
6	Oxyphenbutazone	1.39	3
7	Sertraline	0.69	1
8	Ursolic Acid	0.69	1
9	alsterpaullone	0.69	1
10	Anisomycin	0.69	1
11	Astemizole Antihistamine drug now withdrawn from	0.69	1
12	Calcimycin	0.69	1
13	Chlorhexidine	0.69	1
14	Ciclopirox	0.69	1
15	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	0.69	1
16	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	0.69	1
17	Digoxin	0.69	1
18	Dinitrochlorobenzene	0.69	1
19	Disulfiram	0.69	1
20	Fluspirilene	0.69	1
21	kenpaullone	0.69	1
22	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	0.69	1
23	Mometasone Furoate	0.69	1
24	rafoxanide	0.69	1
25	Sphingosine	0.69	1
26	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	0.69	1
27	Testosterone Propionate	0.69	1
28	Thioridazine	0.69	1
29	Tubercidin	0.69	1
30	tyrphostin 9	0.69	1

About PPP1R15A as a Drug Target

PPP1R15A (protein phosphatase 1, regulatory subunit 15A) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 30 compounds with documented PPP1R15A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PPP1R15A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.