What compounds target PRKCA?

BiohacksAI has identified 39 compounds that interact with PRKCA (protein kinase C, alpha). Top compounds include: tofacitinib, alvocidib, ruxolitinib, midostaurin, abemaciclib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PRKCA (protein kinase C,)?

PRKCA is protein kinase C, alpha. It is a molecular target for 39 compounds documented in PubMed bioassay data. UniProt ID: P05696. NCBI Gene ID: 24680.

PRKCA

MOLECULAR TARGET

protein kinase C, alpha

UniProt: P05696 NCBI Gene: 2468039 compounds

PRKCA (protein kinase C, alpha) is targeted by 39 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PRKCA

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	tofacitinib	4.65	104
2	alvocidib	4.52	91
3	ruxolitinib	4.23	68
4	midostaurin	3.85	46
5	abemaciclib	3.66	38
6	baricitinib	3.56	34
7	gilteritinib	3.40	29
8	gf 109203	3.40	29
9	acetoside	3.40	29
10	bisindolylmaleimide ix	3.14	22
11	at 9283	3.09	21
12	lestaurtinib	3.04	20
13	pacritinib	3.04	20
14	pf 03758309	3.00	19
15	hymenialdisine	3.00	19
16	ruboxistaurin	2.94	18
17	go 6976	2.89	17
18	k 252a	2.83	16
19	ro 316233	2.83	16
20	sotrastaurin	2.77	15
21	capivasertib	2.77	15
22	staurosporinone	2.77	15
23	apitolisib	2.71	14
24	gsk 690693	2.64	13
25	zotiraciclib	2.56	12
26	bms 754807	2.30	9
27	balanol	2.30	9
28	isoxanthohumol	2.30	9
29	decernotinib	2.20	8
30	y 39983	2.20	8
31	enzastaurin	2.08	7
32	uprosertib	1.95	6
33	ucn 01	1.79	5
34	afuresertib	1.79	5
35	sb 242235	1.79	5
36	Minocycline	0.69	1
37	myricetin-3-O-galactopyranoside [Supplementary Concept]	0.69	1
38	Resveratrol	0.69	1
39	Sphingosine	0.69	1

About PRKCA as a Drug Target

PRKCA (protein kinase C, alpha) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 39 compounds with documented PRKCA interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PRKCA inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.