What compounds target PTGS2?

BiohacksAI has identified 51 compounds that interact with PTGS2 (prostaglandin-endoperoxide synthase 2). Top compounds include: Celecoxib, Indomethacin, ns398, Meloxicam, Naproxen. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PTGS2 (prostaglandin-endoperoxide synthase 2)?

PTGS2 is prostaglandin-endoperoxide synthase 2. It is a molecular target for 51 compounds documented in PubMed bioassay data. UniProt ID: P35354. NCBI Gene ID: 5743.

PTGS2

MOLECULAR TARGET

prostaglandin-endoperoxide synthase 2

UniProt: P35354 NCBI Gene: 574351 compounds

PTGS2 (prostaglandin-endoperoxide synthase 2) is targeted by 51 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PTGS2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Celecoxib	5.55	256
2	Indomethacin	4.53	92
3	ns398	3.53	33
4	Meloxicam	2.56	12
5	Naproxen	2.30	9
6	Resveratrol	2.08	7
7	Etodolac	1.61	4
8	sulindac sulfide	1.39	3
9	Arachidonic Acid	1.10	2
10	pterostilbene	1.10	2
11	aphs	1.10	2
12	Oxaprozin	1.10	2
13	sc560	1.10	2
14	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
15	cbd	0.69	1
16	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	0.69	1
17	Quercetin	0.69	1
18	Ursolic Acid	0.69	1
19	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	0.69	1
20	Acetylcysteine	0.69	1
21	butein	0.69	1
22	Calcitriol	0.69	1
23	cannabidiol	0.69	1
24	Cephradine	0.69	1
25	Daunorubicin	0.69	1
26	Epinephrine	0.69	1
27	Ergotamine	0.69	1
28	Hesperidin	0.69	1
29	Indapamide	0.69	1
30	isoetharine	0.69	1
31	Lymecycline	0.69	1
32	Methyldopa	0.69	1
33	monorden	0.69	1
34	Niflumic Acid	0.69	1
35	Norepinephrine Precursor of epinephrine that is secreted by	0.69	1
36	Noscapine	0.69	1
37	Oxymetazoline	0.69	1
38	Oxymetholone	0.69	1
39	Phenylbutazone	0.69	1
40	Procarbazine	0.69	1
41	Rifaximin	0.69	1
42	Rolitetracycline	0.69	1
43	Sorafenib	0.69	1
44	Sulindac	0.69	1
45	Tigecycline	0.69	1
46	tiopronin	0.69	1
47	Tolmetin	0.69	1
48	Tripterygium	0.69	1
49	Troglitazone	0.69	1
50	trolox	0.69	1

Showing top 50 of 51 compounds. Use the BiohacksAI search to explore all PTGS2 modulators.

About PTGS2 as a Drug Target

PTGS2 (prostaglandin-endoperoxide synthase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 51 compounds with documented PTGS2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PTGS2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.