What compounds target PTK2?

BiohacksAI has identified 41 compounds that interact with PTK2 (Focal adhesion kinase 1). Top compounds include: erlotinib, foretinib, ceritinib, bosutinib, doramapimod. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PTK2 (Focal adhesion kinase)?

PTK2 is Focal adhesion kinase 1. It is a molecular target for 41 compounds documented in PubMed bioassay data.

PTK2

MOLECULAR TARGET

Focal adhesion kinase 1

41 compounds

PTK2 (Focal adhesion kinase 1) is targeted by 41 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PTK2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	foretinib	4.34	76
3	ceritinib	4.19	65
4	bosutinib	4.08	58
5	doramapimod	4.06	57
6	bi 2536	4.01	54
7	brigatinib	3.81	44
8	neratinib	3.66	38
9	nintedanib	3.61	36
10	pelitinib	3.50	32
11	tae 684	3.43	30
12	fedratinib	3.40	29
13	alisertib	3.30	26
14	entrectinib	3.18	23
15	rociletinib	3.18	23
16	lestaurtinib	3.04	20
17	repotrectinib	3.00	19
18	danusertib	2.94	18
19	volasertib	2.94	18
20	r 406	2.83	16
21	pf 00562271	2.77	15
22	sotrastaurin	2.77	15
23	hesperadin	2.77	15
24	pha 665752	2.71	14
25	plx 4720	2.71	14
26	enmd 2076	2.71	14
27	kw 2449	2.64	13
28	defactinib	2.48	11
29	lorlatinib	2.48	11
30	azd 7762	2.30	9
31	bms 754807	2.30	9
32	azd 1480	2.30	9
33	su 014813	2.20	8
34	rebastinib	2.20	8
35	cyc 116	2.08	7
36	asp 3026	2.08	7
37	fostamatinib	2.08	7
38	maleimide	1.95	6
39	bastadin 7	1.95	6
40	pf 03814735	1.79	5
41	ucn 01	1.79	5

About PTK2 as a Drug Target

PTK2 (Focal adhesion kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 41 compounds with documented PTK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PTK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.