Question 1

What compounds target RAPGEF4?

Accepted Answer

BiohacksAI has identified 29 compounds that interact with RAPGEF4 (Rap guanine nucleotide exchange factor 4). Top compounds include: Clotrimazole, Cyclic AMP, Cyclic AMP, Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables., Farnesol. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is RAPGEF4 (Rap guanine nucleotide)?

Accepted Answer

RAPGEF4 is Rap guanine nucleotide exchange factor 4. It is a molecular target for 29 compounds documented in PubMed bioassay data. UniProt ID: Q8WZA2. NCBI Gene ID: 11069.

#	Compound	Confidence	Active Assays
1	Clotrimazole	2.30	9
2	Cyclic AMP	2.20	8
3	Cyclic AMP	2.20	8
4	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	1.95	6
5	Farnesol	1.61	4
6	Idarubicin	1.61	4
7	Nitrendipine	1.61	4
8	Trapidil	1.61	4
9	trequinsin hydrochloride	1.61	4
10	myricetin-3-O-galactopyranoside [Supplementary Concept]	1.39	3
11	Hexachlorophene	1.39	3
12	Arachidonic Acid	1.10	2
13	Resveratrol	1.10	2
14	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	1.10	2
15	Alprostadil	1.10	2
16	Amaranth Dye	1.10	2
17	Antimycin	1.10	2
18	Aurintricarboxylic Acid	1.10	2
19	candesartan cilexetil [Supplementary Concept]	1.10	2
20	Daunorubicin	1.10	2
21	Dihydroxyphenylalanine	1.10	2
22	ethopropazine hydrochloride	1.10	2
23	Evans Blue	1.10	2
24	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	1.10	2
25	Loratadine	1.10	2
26	Nocodazole Nocodazole is	1.10	2
27	Masoprocol	1.10	2
28	Perphenazine	1.10	2
29	Piperonyl Butoxide	1.10	2

BiohacksAI

RAPGEF4

Compounds Targeting RAPGEF4

About RAPGEF4 as a Drug Target