What compounds target SC6A4?

BiohacksAI has identified 287 compounds that interact with SC6A4 (Sodium-dependent serotonin transporter). Top compounds include: bdb win 35428 chembl2079586, bdb cbqgyudmjhnjbx, bdb chembl120901 3 naphthalen 2 yl 8 oxa bicyclo 3 2 1 oct 2 ene 2 carboxylic acid m, bdb 3 3 4 dichloro phenyl 8 methyl 8 aza bicyclo 3 2 1 oct 2 ene 2 carboxylic acid m, bdb 3 4 z 2 iodo vinyl phenyl 8 aza bicyclo 3 2 1 octane 2 carboxylic acid methyl es. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is SC6A4 (Sodium-dependent serotonin transporter)?

SC6A4 is Sodium-dependent serotonin transporter. It is a molecular target for 287 compounds documented in PubMed bioassay data.

SC6A4

MOLECULAR TARGET

Sodium-dependent serotonin transporter

287 compounds

SC6A4 (Sodium-dependent serotonin transporter) is targeted by 287 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting SC6A4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	bdb win 35428 chembl2079586	1.79	5
2	bdb cbqgyudmjhnjbx	1.61	4
3	bdb chembl120901 3 naphthalen 2 yl 8 oxa bicyclo 3 2 1 oct 2 ene 2 carboxylic acid m	1.39	3
4	bdb 3 3 4 dichloro phenyl 8 methyl 8 aza bicyclo 3 2 1 oct 2 ene 2 carboxylic acid m	1.39	3
5	bdb 3 4 z 2 iodo vinyl phenyl 8 aza bicyclo 3 2 1 octane 2 carboxylic acid methyl es	1.10	2
6	bdb chembl312037 2s 3s methyl 8 methyl 3 p tolyl 8 aza bicyclo 3 2 1 octane 2 carbox	1.10	2
7	bdb 3 3 4 dichloro phenyl 8 aza bicyclo 3 2 1 octane 2 carboxylic acid methyl ester	1.10	2
8	bdb 3 3 4 dichloro phenyl bicyclo 3 2 1 oct 2 ene 2 carboxylic acid methyl ester 1r	1.10	2
9	bdb 3 4 fluoro phenyl 8 methyl 8 aza bicyclo 3 2 1 oct 2 ene 2 carboxylic acid methy	1.10	2
10	bdb 8 methyl 3 naphthalen 2 yl 8 aza bicyclo 3 2 1 oct 2 ene 2 carboxylic acid methy	1.10	2
11	bdb 8 methyl 3 naphthalen 2 yl 8 aza bicyclo 3 2 1 octane 2 carboxylic acid methyl e	1.10	2
12	bdb chembl1790051 chembl83729 win 35065 2	1.10	2
13	bdb chembl516641 hyperforin	0.69	1
14	bdb chembl2205836	0.69	1
15	bdb n 2 3 fluorophenyl ethyl 8 aminopentacyclo 5 4 0 02 6 03 10 05 9 undecane chembl	0.69	1
16	bdb chembl4789472	0.69	1
17	bdb chembl4746695	0.69	1
18	bdb chembl5078388	0.69	1
19	bdb chembl5081803	0.69	1
20	bdb chembl5086545	0.69	1
21	bdb chembl5091124	0.69	1
22	bdb chembl5093316	0.69	1
23	bdb dextromethorphan us11535596 compound dextromethorphan dm	0.69	1
24	bdb dextrorphan	0.69	1
25	bdb 1 10 di 3beta 4 thiophene 3 yl phenyl tropane 2bcarbonyl amino decane chembl5957	0.69	1
26	bdb 1 3 2 3 3 4 dichloro phenyl 2 methoxycarbonyl 8 azabicyclo 3 2 1 oct 8 yl ethylc	0.69	1
27	bdb 1 3 di 3 4 thiophene 3 yl phenyl tropane 2 carbonylaminomethyl benzene chembl607	0.69	1
28	bdb 1 3beta 4 chloro phenyl tropane 2beta carbonyl oxy 2 4 3beta 4 chloro phenyl tro	0.69	1
29	bdb 1 3beta 4 chloro phenyl tropane 2beta carbonyl oxy 6 4 3beta 4 chloro phenyl tro	0.69	1
30	bdb 1 3beta 4 chloro phenyl tropane 2beta carbonyl oxy 7 4 3beta 4 chloro phenyl tro	0.69	1
31	bdb 1 3beta 4 chlorophenyl tropane 2beta carbonyl amino 1 3beta 4 chlorophenyl tropa	0.69	1
32	bdb 1 3beta 4 chlorophenyl tropane 2beta carbonyl amino 2 3beta 4 chlorophenyl tropa	0.69	1
33	bdb 1 3beta 4 chlorophenyl tropane 2beta carbonyl oxy 5 1 2 3 triazol 1 yl pentane c	0.69	1
34	bdb 1 3beta 4 thiophene 3 yl phenyl tropane 2beta carbonylamino 1 3beta 4 thiophene	0.69	1
35	bdb 1 3beta 4 thiophene 3 yl phenyl tropane 2beta carbonylamino 2 3beta 4 thiophene	0.69	1
36	bdb 1 4 di 3 4 thiophene 3 yl phenyl tropane 2 carbonylaminomethyl benzene chembl595	0.69	1
37	bdb 1 4 di 3beta 4 chlorophenyl tropane 2beta carbonyl amino benzene chembl608704	0.69	1
38	bdb 1 4 di 3beta 4 thiophene 3 yl phenyl tropane 2beta carbonylamino benzene chembl6	0.69	1
39	bdb 1 6 di 3beta 4 thiophene 3 yl phenyl tropane 2beta carbonylamino hexane chembl59	0.69	1
40	bdb 1 8 di 3beta 4 thiophene 3 yl phenyl tropane 2beta carbonylamino octane chembl59	0.69	1
41	bdb 1r 2r 3s 5s 2 2 2 dibromovinyl 8 methyl 3 p tolyl 8 aza bicyclo 3 2 1 octane hyd	0.69	1
42	bdb 1r 2r 3s 5s 3 4 chlorophenyl 2 2 2 dibromovinyl 8 methyl 8 aza bicyclo 3 2 1 oct	0.69	1
43	bdb 1r 2s 3r 5r methyl 3 3 fluoro 4 methylphenyl 8 aza bicyclo 3 2 1 octane 2 carbox	0.69	1
44	bdb 1r 2s 3r 5r methyl 3 4 ethynylphenyl 8 aza bicyclo 3 2 1 octane 2 carboxylate ch	0.69	1
45	bdb 1r 2s 3r 5r methyl 3 4 iodophenyl 8 aza bicyclo 3 2 1 octane 2 carboxylate chemb	0.69	1
46	bdb 1r 2s 3r 5r methyl 3 4 vinylphenyl 8 aza bicyclo 3 2 1 octane 2 carboxylate chem	0.69	1
47	bdb 1r 2s 3r 5r methyl 3 p tolyl 8 aza bicyclo 3 2 1 octane 2 carboxylate chembl2355	0.69	1
48	bdb 1r 2s 3s 5r 3 4 methoxyphenyl 8 methyl 2 3 p tolylisoxazol 5 yl 8 aza bicyclo 3	0.69	1
49	bdb 1r 2s 3s 5r 4 acetamidophenethyl 3 4 methoxyphenyl 8 methyl 8 aza bicyclo 3 2 1	0.69	1
50	bdb 1r 2s 3s 5r 4 amino 3 5 dibromophenethyl 3 4 methoxyphenyl 8 methyl 8 aza bicycl	0.69	1

Showing top 50 of 287 compounds. Use the BiohacksAI search to explore all SC6A4 modulators.

About SC6A4 as a Drug Target

SC6A4 (Sodium-dependent serotonin transporter) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 287 compounds with documented SC6A4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

SC6A4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.