What compounds target SIK2?

BiohacksAI has identified 46 compounds that interact with SIK2 (salt inducible kinase 2). Top compounds include: gefitinib, erlotinib, foretinib, tozasertib, vandetanib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is SIK2 (salt inducible kinase)?

SIK2 is salt inducible kinase 2. It is a molecular target for 46 compounds documented in PubMed bioassay data. UniProt ID: Q9H0K1. NCBI Gene ID: 23235.

SIK2

MOLECULAR TARGET

salt inducible kinase 2

UniProt: Q9H0K1 NCBI Gene: 2323546 compounds

SIK2 (salt inducible kinase 2) is targeted by 46 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting SIK2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	vandetanib	4.30	73
6	bosutinib	4.08	58
7	midostaurin	3.85	46
8	brigatinib	3.81	44
9	pazopanib	3.69	39
10	neratinib	3.66	38
11	nintedanib	3.61	36
12	canertinib	3.53	33
13	pelitinib	3.50	32
14	tae 684	3.43	30
15	fedratinib	3.40	29
16	saracatinib	3.33	27
17	dabrafenib	3.30	26
18	sgi 1776	3.26	25
19	ribociclib	3.26	25
20	dovitinib	3.09	21
21	jnj 7706621	3.09	21
22	at 9283	3.09	21
23	lestaurtinib	3.04	20
24	pf 03758309	3.00	19
25	danusertib	2.94	18
26	momelotinib	2.89	17
27	r 406	2.83	16
28	k 252a	2.83	16
29	cediranib	2.83	16
30	milciclib	2.77	15
31	pha 665752	2.71	14
32	plx 4720	2.71	14
33	crenolanib	2.71	14
34	kw 2449	2.64	13
35	gsk 690693	2.64	13
36	azd 7762	2.30	9
37	aee 788	2.30	9
38	su 014813	2.20	8
39	gsk 1070916	2.20	8
40	cyc 116	2.08	7
41	asp 3026	2.08	7
42	pf 03814735	1.79	5
43	ucn 01	1.79	5
44	osi 632	1.79	5
45	t3 clk	1.79	5
46	Dasatinib	1.39	3

About SIK2 as a Drug Target

SIK2 (salt inducible kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 46 compounds with documented SIK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

SIK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.