What compounds target TIE1?

BiohacksAI has identified 35 compounds that interact with TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1). Top compounds include: erlotinib, foretinib, tozasertib, vandetanib, nilotinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TIE1 (tyrosine kinase with)?

TIE1 is tyrosine kinase with immunoglobulin like and EGF like domains 1. It is a molecular target for 35 compounds documented in PubMed bioassay data. UniProt ID: P35590. NCBI Gene ID: 7075.

TIE1

MOLECULAR TARGET

tyrosine kinase with immunoglobulin like and EGF like domains 1

UniProt: P35590 NCBI Gene: 707535 compounds

TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1) is targeted by 35 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TIE1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	foretinib	4.34	76
3	tozasertib	4.33	75
4	vandetanib	4.30	73
5	nilotinib	4.17	64
6	bosutinib	4.08	58
7	doramapimod	4.06	57
8	quizartinib	3.99	53
9	midostaurin	3.85	46
10	pazopanib	3.69	39
11	neratinib	3.66	38
12	nintedanib	3.61	36
13	canertinib	3.53	33
14	pelitinib	3.50	32
15	tae 684	3.43	30
16	fedratinib	3.40	29
17	linifanib	3.33	27
18	mln 8054	3.33	27
19	dovitinib	3.09	21
20	jnj 7706621	3.09	21
21	lestaurtinib	3.04	20
22	defosbarasertib	2.89	17
23	r 406	2.83	16
24	cediranib	2.83	16
25	pha 665752	2.71	14
26	kw 2449	2.64	13
27	ast 487	2.56	12
28	raf 265	2.48	11
29	brivanib	2.48	11
30	gsk 461364	2.40	10
31	bms 754807	2.30	9
32	su 014813	2.20	8
33	Sorafenib	1.61	4
34	Axitinib	0.69	1
35	Crizotinib	0.69	1

About TIE1 as a Drug Target

TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 35 compounds with documented TIE1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TIE1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.