What compounds target TTK?

BiohacksAI has identified 41 compounds that interact with TTK (TTK protein kinase). Top compounds include: erlotinib, sb 203580, seliciclib, foretinib, tozasertib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TTK (TTK protein kinase)?

TTK is TTK protein kinase. It is a molecular target for 41 compounds documented in PubMed bioassay data. UniProt ID: P33981. NCBI Gene ID: 7272.

TTK

MOLECULAR TARGET

TTK protein kinase

UniProt: P33981 NCBI Gene: 727241 compounds

TTK (TTK protein kinase) is targeted by 41 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TTK

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	sb 203580	4.92	136
3	seliciclib	4.91	135
4	foretinib	4.34	76
5	tozasertib	4.33	75
6	ruxolitinib	4.23	68
7	doramapimod	4.06	57
8	bi 2536	4.01	54
9	midostaurin	3.85	46
10	inamrinone	3.83	45
11	pazopanib	3.69	39
12	sb 202190	3.64	37
13	nintedanib	3.61	36
14	regorafenib	3.56	34
15	tae 684	3.43	30
16	fedratinib	3.40	29
17	mln 8054	3.33	27
18	sp 600125	3.22	24
19	jnj 7706621	3.09	21
20	lestaurtinib	3.04	20
21	danusertib	2.94	18
22	defosbarasertib	2.89	17
23	go 6976	2.89	17
24	r 406	2.83	16
25	k 252a	2.83	16
26	kw 2449	2.64	13
27	mli 2	2.64	13
28	ast 487	2.56	12
29	reversine	2.30	9
30	azd 7648	2.30	9
31	su 014813	2.20	8
32	rebastinib	2.20	8
33	cyc 116	2.08	7
34	tg100 115	2.08	7
35	rg 547	2.08	7
36	dnl 201	1.79	5
37	sp600125	1.61	4
38	Sorafenib	1.39	3
39	Axitinib	0.69	1
40	pictilisib	0.69	1
41	bdb chembl3422102	0.69	1

About TTK as a Drug Target

TTK (TTK protein kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 41 compounds with documented TTK interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TTK inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.