Recognition of DNA damage by PCNA-containing replication complex
REACTOME PATHWAYThe Recognition of DNA damage by PCNA-containing replication complex pathway (Reactome ID: R-HSA-110314) involves 3 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Recognition of DNA damage by PCNA-containing replication complex
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Daunorubicin | — | 298 |
| 2 | Hexachlorophene | — | 300 |
| 3 | Idarubicin | — | 299 |
| 4 | Nitroprusside | — | 299 |
| 5 | Arachidonic Acid | — | 245 |
| 6 | Dehydroepiandrosterone Sulfate | — | 300 |
| 7 | Oleic Acid | — | 112 |
| 8 | plumbagin [Supplementary Concept] | — | 300 |
| 9 | Adapalene | — | 296 |
| 10 | Aurintricarboxylic Acid | — | 184 |
| 11 | Benzethonium Bactericidal cationic quaternary ammonium surfactant used as | — | 96 |
| 12 | candesartan cilexetil [Supplementary Concept] | — | 300 |
| 13 | Cetylpyridinium Cationic bactericidal surfactant used as | — | 300 |
| 14 | Chlorhexidine | — | 299 |
| 15 | Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium. | — | 135 |
| 16 | Estramustine | — | 300 |
| 17 | Ethidium | — | 300 |
| 18 | ethopropazine hydrochloride | — | 2 |
| 19 | Histamine | — | 300 |
| 20 | juglone hydroxylase [Supplementary Concept] catalyzes | — | 279 |
| 21 | Nitrofurantoin | — | 297 |
| 22 | o-Phthalaldehyde | — | 300 |
| 23 | Sodium Dodecyl Sulfate | — | 300 |
| 24 | streptonigrin | — | 299 |
| 25 | Suramin | — | 300 |
| 26 | Oleanolic Acid | — | 300 |
| 27 | Triiodothyronine | — | 300 |
| 28 | ninhydrin | — | 300 |
About the Recognition of DNA damage by PCNA-containing replication complex Pathway
The Recognition of DNA damage by PCNA-containing replication complex pathway is catalogued in Reactome (ID: R-HSA-110314) and involves 3 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PCNA, RBX1, USP1.