What compounds affect the Translesion Synthesis by POLH pathway?

28 compounds in the BiohacksAI corpus have documented interactions with genes in the Translesion Synthesis by POLH pathway (Reactome ID: R-HSA-110320). These compounds target 3 genes within this pathway.

What genes are in the Translesion Synthesis by POLH pathway?

The Translesion Synthesis by POLH pathway involves 3 genes. Key genes include: PCNA, POLH, VCP.

Translesion Synthesis by POLH

REACTOME PATHWAY

Reactome: R-HSA-1103203 genes28 compounds

The Translesion Synthesis by POLH pathway (Reactome ID: R-HSA-110320) involves 3 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

PCNA POLH VCP

Compounds Affecting Translesion Synthesis by POLH

#	Compound	Targets Hit	Studies
1	Hexachlorophene	—	300
2	Oxytetracycline	—	300
3	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
4	Aurintricarboxylic Acid	—	184
5	alpha-Linolenic Acid	—	300
6	Cefixime	—	300
7	Diiodotyrosine	—	300
8	gamma-Linolenic Acid	—	300
9	Levodopa	—	297
10	Kaempferols	—	300
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	Quercetin	—	300
13	ag490	—	14
14	Methotrexate	—	289
15	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
16	Cefotetan	—	299
17	Ethidium	—	300
18	Idarubicin	—	299
19	Masoprocol	—	300
20	Norepinephrine Precursor of epinephrine that is secreted by	—	298
21	piceatannol	—	300
22	streptonigrin	—	299
23	egcg	—	300
24	Clotrimazole	—	296
25	Demeclocycline	—	5
26	Edaravone	—	298
27	Oleanolic Acid	—	300
28	Triiodothyronine	—	300

About the Translesion Synthesis by POLH Pathway

The Translesion Synthesis by POLH pathway is catalogued in Reactome (ID: R-HSA-110320) and involves 3 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PCNA, POLH, VCP.