SHC1 events in ERBB2 signaling
REACTOME PATHWAYThe SHC1 events in ERBB2 signaling pathway (Reactome ID: R-HSA-1250196) involves 5 genes and is affected by 7 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting SHC1 events in ERBB2 signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Afatinib | — | 297 |
| 2 | Dasatinib | — | 299 |
| 3 | tyrphostin ag 1478 | — | 4 |
| 4 | ag490 | — | 14 |
| 5 | tyrphostin 1 | — | 1 |
| 6 | sp600125 | — | 117 |
| 7 | Dactinomycin | — | 297 |
About the SHC1 events in ERBB2 signaling Pathway
The SHC1 events in ERBB2 signaling pathway is catalogued in Reactome (ID: R-HSA-1250196) and involves 5 genes. In the BiohacksAI corpus, 7 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EGFR, ERBB2, ERBB3, ERBB4, GRB2.