Inwardly rectifying K+ channels
REACTOME PATHWAYThe Inwardly rectifying K+ channels pathway (Reactome ID: R-HSA-1296065) involves 7 genes and is affected by 13 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Inwardly rectifying K+ channels
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Cromakalim | — | 300 |
| 2 | Glyburide | — | 298 |
| 3 | gamma-Aminobutyric Acid | — | 300 |
| 4 | Arachidonic Acid | — | 245 |
| 5 | Spermidine | — | 241 |
| 6 | Putrescine | — | 300 |
| 7 | SCH 23390 [Supplementary Concept] | — | 126 |
| 8 | Spermine | — | 300 |
| 9 | Progesterone | — | 299 |
| 10 | dihydrorotenone | — | 13 |
| 11 | streptonigrin | — | 299 |
| 12 | Chlorpropamide | — | 300 |
| 13 | Nortriptyline | — | 295 |
About the Inwardly rectifying K+ channels Pathway
The Inwardly rectifying K+ channels pathway is catalogued in Reactome (ID: R-HSA-1296065) and involves 7 genes. In the BiohacksAI corpus, 13 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC8, ABCC9, GABBR1, GABBR2, KCNJ1.