What compounds affect the Polo-like kinase mediated events pathway?

30 compounds in the BiohacksAI corpus have documented interactions with genes in the Polo-like kinase mediated events pathway (Reactome ID: R-HSA-156711). These compounds target 8 genes within this pathway.

What genes are in the Polo-like kinase mediated events pathway?

The Polo-like kinase mediated events pathway involves 8 genes. Key genes include: CCNB1, CCNB2, CDC25A, EP300, FOXM1, PKMYT1, PLK1, WEE1.

Polo-like kinase mediated events

REACTOME PATHWAY

Reactome: R-HSA-1567118 genes30 compounds

The Polo-like kinase mediated events pathway (Reactome ID: R-HSA-156711) involves 8 genes and is affected by 30 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNB1 CCNB2 CDC25A EP300 FOXM1 PKMYT1 PLK1 WEE1

Compounds Affecting Polo-like kinase mediated events

#	Compound	Targets Hit	Studies
1	indirubin	—	300
2	kenpaullone	—	8
3	alsterpaullone	—	12
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	chrysin	—	300
6	fisetin	—	78
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	plumbagin [Supplementary Concept]	—	300
9	ly294002	—	11
10	Wortmannin	—	300
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
12	Oleic Acid	—	112
13	Quercetin	—	300
14	Simvastatin	—	1,000
15	cefaclor	—	299
16	Disulfiram	—	297
17	Hexachlorophene	—	300
18	Lithocholic Acid	—	300
19	Nisoldipine	—	297
20	Oxyphenbutazone	—	300
21	Oxytetracycline	—	300
22	Fluocinonide	—	196
23	Pemoline	—	300
24	Sulfaguanidine	—	255
25	Ursodeoxycholic Acid	—	298
26	egcg	—	300
27	11-hydroxypalmatine [Supplementary Concept]	—	238
28	Vitamin K 3	—	300
29	Dasatinib	—	299
30	Troglitazone	—	299

About the Polo-like kinase mediated events Pathway

The Polo-like kinase mediated events pathway is catalogued in Reactome (ID: R-HSA-156711) and involves 8 genes. In the BiohacksAI corpus, 30 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNB1, CCNB2, CDC25A, EP300, FOXM1.