Gap junction trafficking and regulation
REACTOME PATHWAYThe Gap junction trafficking and regulation pathway (Reactome ID: R-HSA-157858) involves 19 genes and is affected by 22 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Gap junction trafficking and regulation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Colchicine | — | 300 |
| 2 | Nocodazole Nocodazole is | — | 215 |
| 3 | Vincristine | — | 299 |
| 4 | Noscapine | — | 300 |
| 5 | Podophyllotoxin | — | 14 |
| 6 | Demecolcine | — | 246 |
| 7 | Maytansine | — | 300 |
| 8 | vinblastine sulfate | — | 81 |
| 9 | Vorinostat | — | 299 |
| 10 | Dasatinib | — | 299 |
| 11 | Resveratrol | — | 298 |
| 12 | tyrphostin ag 1478 | — | 4 |
| 13 | Sorafenib | — | 300 |
| 14 | Quercetin | — | 300 |
| 15 | Adenosine Monophosphate Adenine nucleotide containing | — | 300 |
| 16 | Afatinib | — | 297 |
| 17 | alsterpaullone | — | 12 |
| 18 | Crizotinib | — | 298 |
| 19 | kenpaullone | — | 8 |
| 20 | monorden | — | 8 |
| 21 | Niclosamide | — | 299 |
| 22 | Kanamycin Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, | — | 300 |
About the Gap junction trafficking and regulation Pathway
The Gap junction trafficking and regulation pathway is catalogued in Reactome (ID: R-HSA-157858) and involves 19 genes. In the BiohacksAI corpus, 22 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GJB2, SRC, TUBA1A, TUBA1B, TUBA1C.