What compounds affect the Signalling to RAS pathway?

24 compounds in the BiohacksAI corpus have documented interactions with genes in the Signalling to RAS pathway (Reactome ID: R-HSA-167044). These compounds target 8 genes within this pathway.

What genes are in the Signalling to RAS pathway?

The Signalling to RAS pathway involves 8 genes. Key genes include: GRB2, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, NTRK1, SRC.

Signalling to RAS

REACTOME PATHWAY

Reactome: R-HSA-1670448 genes24 compounds

The Signalling to RAS pathway (Reactome ID: R-HSA-167044) involves 8 genes and is affected by 24 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GRB2 MAPK11 MAPK12 MAPK13 MAPK14 MAPKAPK2 NTRK1 SRC

Compounds Affecting Signalling to RAS

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Afatinib	—	297
3	Anisomycin	—	247
4	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
5	withaferin	—	300
6	Dasatinib	—	299
7	Quercetin	—	300
8	tyrphostin ag 1478	—	4
9	Crizotinib	—	298
10	sp600125	—	117
11	egcg	—	300
12	fisetin	—	78
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Celecoxib	—	295
15	Resveratrol	—	298
16	Adenosine Monophosphate Adenine nucleotide containing	—	300
17	alsterpaullone	—	12
18	kenpaullone	—	8
19	monorden	—	8
20	Niclosamide	—	299
21	Axitinib	—	298
22	pictilisib	—	25
23	Adenosine Triphosphate	—	300
24	Dactinomycin	—	297

About the Signalling to RAS Pathway

The Signalling to RAS pathway is catalogued in Reactome (ID: R-HSA-167044) and involves 8 genes. In the BiohacksAI corpus, 24 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, MAPK11, MAPK12, MAPK13, MAPK14.