TICAM1, RIP1-mediated IKK complex recruitment
REACTOME PATHWAYThe TICAM1, RIP1-mediated IKK complex recruitment pathway (Reactome ID: R-HSA-168927) involves 5 genes and is affected by 24 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting TICAM1, RIP1-mediated IKK complex recruitment
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | chicoric acid | — | 117 |
| 2 | naringin | — | 300 |
| 3 | Chlorhexidine | — | 299 |
| 4 | Perphenazine | — | 297 |
| 5 | Sphingosine | — | 300 |
| 6 | Resveratrol | — | 298 |
| 7 | Sertraline | — | 1,000 |
| 8 | Astemizole Antihistamine drug now withdrawn from | — | 280 |
| 9 | Canrenone | — | 300 |
| 10 | Thioridazine | — | 35 |
| 11 | Budesonide | — | 1,000 |
| 12 | Dibucaine | — | 299 |
| 13 | Dimethylphenylpiperazinium Iodide | — | 33 |
| 14 | Edaravone | — | 298 |
| 15 | Fluocinolone Acetonide | — | 295 |
| 16 | Podophyllotoxin | — | 14 |
| 17 | Sulfadimethoxine | — | 300 |
| 18 | vinblastine sulfate | — | 81 |
| 19 | alsterpaullone | — | 12 |
| 20 | Aurintricarboxylic Acid | — | 184 |
| 21 | Crizotinib | — | 298 |
| 22 | sp600125 | — | 117 |
| 23 | glaucarubinone | — | 10 |
| 24 | Vemurafenib | — | 298 |
About the TICAM1, RIP1-mediated IKK complex recruitment Pathway
The TICAM1, RIP1-mediated IKK complex recruitment pathway is catalogued in Reactome (ID: R-HSA-168927) and involves 5 genes. In the BiohacksAI corpus, 24 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHUK, IKBKB, RIPK3, TLR3, UBE2N.