What compounds affect the Adenylate cyclase inhibitory pathway pathway?

30 compounds in the BiohacksAI corpus have documented interactions with genes in the Adenylate cyclase inhibitory pathway pathway (Reactome ID: R-HSA-170670). These compounds target 2 genes within this pathway.

What genes are in the Adenylate cyclase inhibitory pathway pathway?

The Adenylate cyclase inhibitory pathway pathway involves 2 genes. Key genes include: ADCY9, GNAI1.

Adenylate cyclase inhibitory pathway

REACTOME PATHWAY

Reactome: R-HSA-1706702 genes30 compounds

The Adenylate cyclase inhibitory pathway pathway (Reactome ID: R-HSA-170670) involves 2 genes and is affected by 30 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 GNAI1

Compounds Affecting Adenylate cyclase inhibitory pathway

#	Compound	Targets Hit	Studies
1	Aurintricarboxylic Acid	—	184
2	Daunorubicin	—	298
3	Ethidium	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Rosmarinic Acid	—	300
6	Allantoin	—	300
7	Diiodotyrosine	—	300
8	Dimethylphenylpiperazinium Iodide	—	33
9	Dipyrone	—	298
10	Idarubicin	—	299
11	iodoform	—	272
12	Nicergoline	—	300
13	Pseudoephedrine	—	298
14	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
15	tiopronin	—	299
16	tyrphostin ag 1478	—	4
17	Carmustine	—	297
18	Edaravone	—	298
19	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
20	Iodoacetamide	—	300
21	Cisplatin	—	300
22	Cilostazol	—	297
23	Disulfiram	—	297
24	Physostigmine	—	300
25	Ethylmaleimide	—	300
26	Physostigmine	—	299
27	tyrphostin 1	—	1
28	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
29	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
30	Diamide	—	300

About the Adenylate cyclase inhibitory pathway Pathway

The Adenylate cyclase inhibitory pathway pathway is catalogued in Reactome (ID: R-HSA-170670) and involves 2 genes. In the BiohacksAI corpus, 30 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, GNAI1.