What genes are in the Removal of the Flap Intermediate from the C-strand pathway?

The Removal of the Flap Intermediate from the C-strand pathway involves 4 genes. Key genes include: DNA2, FEN1, PCNA, WRN.

Removal of the Flap Intermediate from the C-strand

Q: What compounds affect the Removal of the Flap Intermediate from the C-strand pathway?

27 compounds in the BiohacksAI corpus have documented interactions with genes in the Removal of the Flap Intermediate from the C-strand pathway (Reactome ID: R-HSA-174437). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-1744374 genes27 compounds

The Removal of the Flap Intermediate from the C-strand pathway (Reactome ID: R-HSA-174437) involves 4 genes and is affected by 27 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

DNA2 FEN1 PCNA WRN

Compounds Affecting Removal of the Flap Intermediate from the C-strand

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Ethidium	—	300
3	Levodopa	—	297
4	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
5	Oxytetracycline	—	300
6	Quercetin	—	300
7	Aurintricarboxylic Acid	—	184
8	Norepinephrine Precursor of epinephrine that is secreted by	—	298
9	Dequalinium	—	136
10	Diiodotyrosine	—	300
11	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
12	Epinephrine	—	299
13	Idarubicin	—	299
14	Methyldopa	—	297
15	piceatannol	—	300
16	Doxycycline	—	999
17	Methylene Blue	—	200
18	Carmine Coloring matter from	—	300
19	Cisplatin	—	300
20	Demeclocycline	—	297
21	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
22	streptonigrin	—	299
23	alpha-Linolenic Acid	—	300
24	Masoprocol	—	300
25	Oleanolic Acid	—	300
26	Triiodothyronine	—	300
27	Uridine Triphosphate Uridine 5'-(tetrahydrogen triphosphate).	—	300

About the Removal of the Flap Intermediate from the C-strand Pathway

The Removal of the Flap Intermediate from the C-strand pathway is catalogued in Reactome (ID: R-HSA-174437) and involves 4 genes. In the BiohacksAI corpus, 27 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DNA2, FEN1, PCNA, WRN.