What compounds affect the Vif-mediated degradation of APOBEC3G pathway?

26 compounds in the BiohacksAI corpus have documented interactions with genes in the Vif-mediated degradation of APOBEC3G pathway (Reactome ID: R-HSA-180585). These compounds target 34 genes within this pathway.

What genes are in the Vif-mediated degradation of APOBEC3G pathway?

The Vif-mediated degradation of APOBEC3G pathway involves 34 genes. Key genes include: ADRM1, APOBEC3G, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1.

Vif-mediated degradation of APOBEC3G

REACTOME PATHWAY

Reactome: R-HSA-18058534 genes26 compounds

The Vif-mediated degradation of APOBEC3G pathway (Reactome ID: R-HSA-180585) involves 34 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 APOBEC3G PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6+4 more

Compounds Affecting Vif-mediated degradation of APOBEC3G

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
4	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
5	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
6	Anthralin	—	299
7	sulfameter	—	52
8	DEAD-box RNA Helicases	—	169
9	Thioctic Acid	—	298
10	Resveratrol	—	298
11	Cefotetan	—	299
12	Dimethylphenylpiperazinium Iodide	—	33
13	mg624	—	3
14	streptonigrin	—	299
15	Thioctic Acid	—	300
16	Disulfiram	—	297
17	4-Hydroxybenzoate-3-Monooxygenase	—	300
18	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
19	chrysin	—	300
20	egcg	—	300
21	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
22	Quercetin	—	300
23	Genistein	—	300
24	Pioglitazone	—	297
25	Harmaline	—	300
26	ninhydrin	—	300

About the Vif-mediated degradation of APOBEC3G Pathway

The Vif-mediated degradation of APOBEC3G pathway is catalogued in Reactome (ID: R-HSA-180585) and involves 34 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, APOBEC3G, PSMA1, PSMA2, PSMA3.