PI3K/AKT activation
REACTOME PATHWAYThe PI3K/AKT activation pathway (Reactome ID: R-HSA-198203) involves 4 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting PI3K/AKT activation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | pictilisib | — | 25 |
| 2 | ly294002 | — | 11 |
| 3 | Sirolimus | — | 300 |
| 4 | Wortmannin | — | 300 |
| 5 | alpelisib | — | 227 |
| 6 | torin 1 | — | 10 |
| 7 | Quercetin | — | 300 |
| 8 | Resveratrol | — | 298 |
| 9 | Crizotinib | — | 298 |
| 10 | Sorafenib | — | 300 |
| 11 | Axitinib | — | 298 |
| 12 | sp600125 | — | 117 |
About the PI3K/AKT activation Pathway
The PI3K/AKT activation pathway is catalogued in Reactome (ID: R-HSA-198203) and involves 4 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include NTRK1, PIK3CB, PIK3R1, PIK3R2.