Signalling to ERK5
REACTOME PATHWAYThe Signalling to ERK5 pathway (Reactome ID: R-HSA-198765) involves 2 genes and is affected by 5 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Signalling to ERK5
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Afatinib | — | 297 |
| 2 | Axitinib | — | 298 |
| 3 | Sorafenib | — | 300 |
| 4 | Vemurafenib | — | 298 |
| 5 | Crizotinib | — | 298 |
About the Signalling to ERK5 Pathway
The Signalling to ERK5 pathway is catalogued in Reactome (ID: R-HSA-198765) and involves 2 genes. In the BiohacksAI corpus, 5 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MAP2K5, MAPK7.