What compounds affect the ER to Golgi Anterograde Transport pathway?

27 compounds in the BiohacksAI corpus have documented interactions with genes in the ER to Golgi Anterograde Transport pathway (Reactome ID: R-HSA-199977). These compounds target 22 genes within this pathway.

What genes are in the ER to Golgi Anterograde Transport pathway?

The ER to Golgi Anterograde Transport pathway involves 22 genes. Key genes include: CSNK1D, F5, FOLR1, GRIA1, INS, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3E.

ER to Golgi Anterograde Transport

REACTOME PATHWAY

Reactome: R-HSA-19997722 genes27 compounds

The ER to Golgi Anterograde Transport pathway (Reactome ID: R-HSA-199977) involves 22 genes and is affected by 27 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CSNK1D F5 FOLR1 GRIA1 INS TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B

Compounds Affecting ER to Golgi Anterograde Transport

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Vincristine	—	299
4	Noscapine	—	300
5	Podophyllotoxin	—	14
6	Demecolcine	—	246
7	Maytansine	—	300
8	vinblastine sulfate	—	81
9	Vorinostat	—	299
10	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	—	300
11	Glutamic Acid	—	297
12	Glutamic Acid	—	300
13	Piracetam	—	300
14	aniracetam	—	110
15	Digitoxin	—	300
16	Digoxin	—	299
17	Flutamide	—	298
18	m084	—	2
19	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
20	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
21	sp600125	—	117
22	alsterpaullone	—	12
23	pictilisib	—	25
24	Pemetrexed	—	299
25	Methotrexate	—	289
26	Folic Acid	—	296
27	apixaban [Supplementary Concept]	—	997

About the ER to Golgi Anterograde Transport Pathway

The ER to Golgi Anterograde Transport pathway is catalogued in Reactome (ID: R-HSA-199977) and involves 22 genes. In the BiohacksAI corpus, 27 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSNK1D, F5, FOLR1, GRIA1, INS.