What compounds affect the G-protein activation pathway?

54 compounds in the BiohacksAI corpus have documented interactions with genes in the G-protein activation pathway (Reactome ID: R-HSA-202040). These compounds target 2 genes within this pathway.

What genes are in the G-protein activation pathway?

The G-protein activation pathway involves 2 genes. Key genes include: GNA15, OPRM1.

G-protein activation

REACTOME PATHWAY

Reactome: R-HSA-2020402 genes54 compounds

The G-protein activation pathway (Reactome ID: R-HSA-202040) involves 2 genes and is affected by 54 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GNA15 OPRM1

Compounds Affecting G-protein activation

#	Compound	Targets Hit	Studies
1	Fluspirilene	—	74
2	Morphine	—	294
3	Naloxone	—	299
4	Fentanyl	—	300
5	Nalbuphine	—	298
6	Butorphanol	—	299
7	Oxycodone	—	298
8	Levorphanol	—	297
9	Nalorphine	—	300
10	Pentazocine	—	299
11	Diprenorphine	—	295
12	Sufentanil	—	298
13	Levallorphan	—	289
14	Meperidine	—	297
15	Codeine	—	295
16	Etorphine	—	300
17	cbd	—	298
18	cannabidiol	—	296
19	Dihydromorphine	—	300
20	Meptazinol	—	231
21	Alfentanil	—	298
22	Hydromorphone	—	297
23	Tramadol	—	1,000
24	Cyclazocine	—	300
25	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
26	hydrocodone	—	294
27	Ibogaine	—	300
28	Thebaine	—	297
29	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
30	Kaempferols	—	300
31	alpha-Endorphin	—	188
32	alsterpaullone	—	12
33	beta-Endorphin	—	300
34	Buprenorphine	—	297
35	Celecoxib	—	295
36	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
37	Digoxin	—	299
38	Dihydroergotamine	—	9
39	Diphenoxylate	—	294
40	Flunarizine Flunarizine is	—	14
41	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
42	Ondansetron	—	299
43	Phenazocine	—	80
44	Ritodrine	—	87
45	Somatostatin	—	300
46	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
47	alphitonin [Supplementary Concept] from	—	300
48	Aripiprazole	—	298
49	Bisphenol A-Glycidyl Methacrylate	—	197
50	Calcimycin	—	216

About the G-protein activation Pathway

The G-protein activation pathway is catalogued in Reactome (ID: R-HSA-202040) and involves 2 genes. In the BiohacksAI corpus, 54 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GNA15, OPRM1.