What genes are in the Glutamate Neurotransmitter Release Cycle pathway?

The Glutamate Neurotransmitter Release Cycle pathway involves 4 genes. Key genes include: GLS, SLC1A1, SLC1A2, SLC1A3.

Glutamate Neurotransmitter Release Cycle

Q: What compounds affect the Glutamate Neurotransmitter Release Cycle pathway?

34 compounds in the BiohacksAI corpus have documented interactions with genes in the Glutamate Neurotransmitter Release Cycle pathway (Reactome ID: R-HSA-210500). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-2105004 genes34 compounds

The Glutamate Neurotransmitter Release Cycle pathway (Reactome ID: R-HSA-210500) involves 4 genes and is affected by 34 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GLS SLC1A1 SLC1A2 SLC1A3

Compounds Affecting Glutamate Neurotransmitter Release Cycle

#	Compound	Targets Hit	Studies
1	Aspartic Acid	—	300
2	Glutamic Acid	—	297
3	Glutamic Acid	—	300
4	caffeic acid	—	300
5	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
6	Resveratrol	—	298
7	2-Methoxyestradiol	—	300
8	ag490	—	14
9	alpha-Linolenic Acid	—	300
10	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
11	Calcimycin	—	216
12	cefaclor	—	299
13	cefatrizine	—	114
14	Cefixime	—	300
15	daph	—	2
16	Diazooxonorleucine	—	32
17	Disulfiram	—	297
18	Physostigmine	—	300
19	ethopropazine	—	17
20	Fenoterol	—	300
21	hydroxyindoleacetic acid	—	300
22	Hydroxyurea	—	300
23	Metaproterenol	—	298
24	methoxyhydroxyphenylglycol	—	64
25	Normetanephrine	—	300
26	Oxytetracycline	—	300
27	Physostigmine	—	299
28	piceatannol	—	300
29	Reserpine	—	297
30	Rotenone	—	300
31	Suramin	—	300
32	Tolazamide	—	169
33	tyrphostin 9	—	2
34	D-Aspartic Acid	—	29

About the Glutamate Neurotransmitter Release Cycle Pathway

The Glutamate Neurotransmitter Release Cycle pathway is catalogued in Reactome (ID: R-HSA-210500) and involves 4 genes. In the BiohacksAI corpus, 34 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GLS, SLC1A1, SLC1A2, SLC1A3.