Tie2 Signaling
REACTOME PATHWAYThe Tie2 Signaling pathway (Reactome ID: R-HSA-210993) involves 5 genes and is affected by 14 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Tie2 Signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | pictilisib | — | 25 |
| 2 | ly294002 | — | 11 |
| 3 | Sirolimus | — | 300 |
| 4 | Wortmannin | — | 300 |
| 5 | alpelisib | — | 227 |
| 6 | torin 1 | — | 10 |
| 7 | Quercetin | — | 300 |
| 8 | Resveratrol | — | 298 |
| 9 | Sorafenib | — | 300 |
| 10 | Crizotinib | — | 298 |
| 11 | Ampicillin Semi-synthetic derivative of penicillin that functions as | — | 294 |
| 12 | Axitinib | — | 298 |
| 13 | Cetirizine | — | 296 |
| 14 | Dactinomycin | — | 297 |
About the Tie2 Signaling Pathway
The Tie2 Signaling pathway is catalogued in Reactome (ID: R-HSA-210993) and involves 5 genes. In the BiohacksAI corpus, 14 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, PIK3CB, PIK3R1, PIK3R2, TEK.