Activation of PPARGC1A (PGC-1alpha) by phosphorylation
REACTOME PATHWAYThe Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway (Reactome ID: R-HSA-2151209) involves 9 genes and is affected by 25 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Activation of PPARGC1A (PGC-1alpha) by phosphorylation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Adenosine Monophosphate Adenine nucleotide containing | — | 300 |
| 2 | Proguanil | — | 299 |
| 3 | Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone | — | 76 |
| 4 | Niclosamide | — | 299 |
| 5 | Berberine | — | 300 |
| 6 | Ursolic Acid | — | 300 |
| 7 | Antimycin | — | 300 |
| 8 | Oleanolic Acid | — | 300 |
| 9 | Rotenone | — | 300 |
| 10 | Metformin | — | 1,000 |
| 11 | Sorafenib | — | 300 |
| 12 | Anisomycin | — | 247 |
| 13 | isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from | — | 300 |
| 14 | withaferin | — | 300 |
| 15 | Quercetin | — | 300 |
| 16 | Dasatinib | — | 299 |
| 17 | Afatinib | — | 297 |
| 18 | Kaempferols | — | 300 |
| 19 | Rutin | — | 300 |
| 20 | egcg | — | 300 |
| 21 | fisetin | — | 78 |
| 22 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 23 | Celecoxib | — | 295 |
| 24 | tyrphostin ag 1478 | — | 4 |
| 25 | sp600125 | — | 117 |
About the Activation of PPARGC1A (PGC-1alpha) by phosphorylation Pathway
The Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway is catalogued in Reactome (ID: R-HSA-2151209) and involves 9 genes. In the BiohacksAI corpus, 25 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MAPK11, MAPK12, MAPK14, PRKAA2, PRKAB1.